tag:blogger.com,1999:blog-5977689274110133568.post6650239843219589017..comments2016-03-20T21:22:37.657-07:00Comments on The Daily Lipid: Wheat: In Search of Scientific Objectivity and New Year's ResolutionsChris Masterjohnhttp://www.blogger.com/profile/09922003080748568167noreply@blogger.comBlogger37125tag:blogger.com,1999:blog-5977689274110133568.post-78468414439886765642015-11-25T18:23:53.672-08:002015-11-25T18:23:53.672-08:0020151126dongdong coach outlet nike free runs coach...20151126dongdong<br /><a href="http://coach.outletmalls.us.com" rel="nofollow"><strong>coach outlet</strong></a><br /><a href="http://www.nikefreeruns.uk" rel="nofollow"><strong>nike free runs</strong></a><br /><a href="http://www.coachoutlet-storeonline.us.com" rel="nofollow"><strong>coach factory outlet</strong></a><br /><a href="http://www.michaelkorsoutletforus.com" rel="nofollow"><strong>michael kors</strong></a><br /><a href="http://www.michaelkorshandbags.cc" rel="nofollow"><strong>michael kors handbags</strong></a><br /><a href="http://www.moncler-jackets.org" rel="nofollow"><strong>moncler jackets</strong></a><br /><a href="http://www.louisvuitton-macys.com" rel="nofollow"><strong>louis vuitton outlet</strong></a><br /><a href="http://www.jordan13.org" rel="nofollow"><strong>air jordan 13</strong></a><br /><a href="http://uggs.uggaustralia.qc.com" rel="nofollow"><strong>ugg boots </strong></a><br /><a href="http://www.northfaceuk.org.uk" rel="nofollow"><strong>north face</strong></a><br /><a href="http://www.louisvuitton-macys.com" rel="nofollow"><strong>louis vuitton</strong></a><br /><a href="http://www.toryburchoutlet-sale.in.net" rel="nofollow"><strong>tory burch outlet</strong></a><br /><a href="http://www.louis-vuitton-outlet.us.com" rel="nofollow"><strong>louis vuitton outlet</strong></a><br /><a href="http://www.truereligion-outlet.in.net" rel="nofollow"><strong>true religion jeans</strong></a><br /><a href="http://www.authenticlouisvuittonhandbags.net" rel="nofollow"><strong>louis vuitton bags</strong></a><br /><a href="http://burberry.outletmalls.us.com" rel="nofollow"><strong>burberry outlet</strong></a><br /><a href="http://www.truereligion-outlet.in.net" rel="nofollow"><strong>true religion outlet</strong></a><br /><a href="http://www.nike-airmax.org.uk" rel="nofollow"><strong>nike air max</strong></a><br /><a href="http://www.katespadeuk.me.uk" rel="nofollow"><strong>kate spade uk</strong></a><br /><a href="http://www.michaelkors-outletonlines.in.net" rel="nofollow"><strong>michael kors outlet</strong></a><br /><a href="http://www.nikeblazers.me.uk" rel="nofollow"><strong>nike blazers</strong></a><br /><a href="http://www.nikeuk.me.uk" rel="nofollow"><strong>nike trainers</strong></a><br /><a href="http://www.coachfactoryoutletus.in.net" rel="nofollow"><strong>coach factory outlet</strong></a><br /><a href="http://www.coach-factoryoutlet.cc" rel="nofollow"><strong>coach factory outlet</strong></a><br /><a href="http://www.sunglass-outlet.us" rel="nofollow"><strong>ray ban sunglasses</strong></a><br /><a href="http://www.oakleysunglassesfake.in.net" rel="nofollow"><strong>fake oakley sunglasses</strong></a><br /><a href="http://www.cheapwholesaleuggboots.com" rel="nofollow"><strong>ugg boots</strong></a><br /><a href="http://www.coachcanadaoutlet.ca" rel="nofollow"><strong>coach outlet</strong></a><br /><a href="http://www.saclongchamp--pascher.fr" rel="nofollow"><strong>sac longchamp</strong></a><br /><a href="http://www.quality-outlet.com" rel="nofollow"><strong>nike outlet</strong></a><br /><a href="http://jordan.outletmalls.us.com" rel="nofollow"><strong>cheap jordans</strong></a><br /><a href="http://www.ralph-lauren.me.uk" rel="nofollow"><strong>ralph lauren uk</strong></a><br /><a href="http://www.nikerosheruns.me.uk" rel="nofollow"><strong>nike roshe runs</strong></a><br /><a href="http://www.montblanc-pens.name" rel="nofollow"><strong>mont blanc pens</strong></a><br /><a href="http://www.kate-spadeoutlet.com.co" rel="nofollow"><strong>kate spade outlet</strong></a><br /><a href="http://www.louisvuittonuk.me.uk" rel="nofollow"><strong>louis vuitton outlet</strong></a><br /><a href="http://www.edhardy-outlet.name" rel="nofollow"><strong>ed hardy outlet</strong></a><br /><a href="http://www.barbouruk.org.uk" rel="nofollow"><strong>barbour uk</strong></a><br /><a href="http://www.jordan4.net" rel="nofollow"><strong>jordan 4 toro</strong></a><br /><a href="http://www.raybansoutlet.in.net" rel="nofollow"><strong>ray bans</strong></a><br />Dong Donghttp://www.blogger.com/profile/14503282237101357040noreply@blogger.comtag:blogger.com,1999:blog-5977689274110133568.post-31105304155669228662012-12-15T18:39:12.112-08:002012-12-15T18:39:12.112-08:00i just want to say that this is a fantastic dialog...i just want to say that this is a fantastic dialogue, with a very impressive group of participants, and I&#39;m not referring to myself; naturally, I&#39;m talking about input from people like Paul Jaminet and Chris Masterjohn.Marilyn Christianhttp://www.blogger.com/profile/15165536249335294320noreply@blogger.comtag:blogger.com,1999:blog-5977689274110133568.post-2841621999989359192011-09-05T13:33:44.167-07:002011-09-05T13:33:44.167-07:00Considering our government has recommended tons of...Considering our government has recommended tons of grain<br />consumption daily for maximum health for decades and continues to<br />subsidize corn farmers, it&#39;s not too much of a stretch to see why<br />government research into the health hazards of grains has been slow<br />coming.Stevehttp://www.paleodietfoodlist.net/paleo-diet-food-listnoreply@blogger.comtag:blogger.com,1999:blog-5977689274110133568.post-55247589850771062912011-08-03T02:39:28.952-07:002011-08-03T02:39:28.952-07:00Chris, thanks for this post. Gluten can be a of th...Chris, thanks for this post. Gluten can be a of the many complex proteins ingested by man - and is therefore extremely hard to digest. This is why babies first introduced to solid meals are not given wheat. They are started on a thin porridge of rice because their small digestive tract can process it very easily.<br /><br />Most people with Gluten intolerance are incapable to digest gluten - a protein found in wheat, rye, barley and oats. In fact in Celiacs this protein actually attacks the lining of the small intestine producing injury that flattens out the tiny villiLuishttp://losinghairv.com/noreply@blogger.comtag:blogger.com,1999:blog-5977689274110133568.post-13942030382169240212011-01-24T13:48:55.880-08:002011-01-24T13:48:55.880-08:00Chris and Matt L, the Sikhs ate fresh ground whole...Chris and Matt L, the Sikhs ate fresh ground whole wheat with robust health. Robert McCarrison studied and wrote about the indigenous people of India around the same time Weston Price traveled and wrote. Some of RM&#39;s books are available online. For a summary, see Matt Stone&#39;s blog, 180 Degree Health, and search for posts tagged Robert McCarrison or just McCarrison.<br /><br />I think the Hunza and some other healthy groups ate wheat, as well as the people on Crete that Chris mentions. To say you are not aware of any healthy people eating wheat is ignorant, as they have been brought up repeatedly on various blogs. Even Stephan conceded that the rancidity of flour, esp whole wheat, and the toxc chemical bleaching that creaes alloxan, and the synthetic vitamins and minerals used in enriching, could be large factors in whea related problems.<br /><br />Also, Matt, you ignore other confounders that could be at fault like the pufa oils, canola oil, hydrogenated oils, and so on that are almost ubiquitous in store bought breads. Even the health food store breads mosty use refined and/or rancid pufa oils.<br /><br />Ian/BruceIanhttp://www.blogger.com/profile/06765420888898235183noreply@blogger.comtag:blogger.com,1999:blog-5977689274110133568.post-54831731629217263862011-01-20T22:23:52.449-08:002011-01-20T22:23:52.449-08:00If you&#39;re that worried about gluten, but don&#...If you&#39;re that worried about gluten, but don&#39;t want to give up bread try some traditionally made artisan bread:<br /><br />http://www.cghjournal.org/article/S1542-3565(10)00987-0/abstractmatthewhttp://www.geekbeast.comnoreply@blogger.comtag:blogger.com,1999:blog-5977689274110133568.post-57770754723055554932011-01-11T14:21:19.326-08:002011-01-11T14:21:19.326-08:00Chris - what about the &quot;leaky gut&quot; effec...Chris - what about the &quot;leaky gut&quot; effects of WGA/gluten? Even though this study is pretty much worthless - are there not others that make a stronger link to unfortunate responses to gluten in non-celiac persons? <br /><br />I have seem lots of pretty damning &quot;could be&quot; arguments/research pointing at gluten for thing form schizophrenia to MS, IBS to Rheumatoid arthritis (and auto-immune disorder) - are these not more frightening postulations than the study you just effectively deconstructed?<br />thanks!<br /><br />Ravi<br />Discoveries for a Full LifeRavihttp://daiasolgaia.wordpress.comnoreply@blogger.comtag:blogger.com,1999:blog-5977689274110133568.post-44592644271120998002011-01-11T10:57:37.071-08:002011-01-11T10:57:37.071-08:00Chris, Another intelligent post! I like the fact ...Chris,<br /><br />Another intelligent post! I like the fact that you keep it real and scientific and don&#39;t get tangled up in your own bias. <br /><br />STGAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-5977689274110133568.post-53228137835368972182011-01-10T03:17:29.748-08:002011-01-10T03:17:29.748-08:00Hi, regarding your panic attack maybe I found an e...Hi, regarding your panic attack maybe I found an explanation. Gluten and casein have opiates activity.<br /><br />http://www.csa.com/discoveryguides/thyroid/overview.php<br /><br />&quot;Paradoxically, some substances labelled depressants such as alcohol or opiates can increase T3 levels by impairing the breakdown of T3 in the brain, thus lifting mood. This may be one reason why these substances are so addictive.&quot;snaidernoreply@blogger.comtag:blogger.com,1999:blog-5977689274110133568.post-90336984771712544962011-01-08T14:18:12.900-08:002011-01-08T14:18:12.900-08:00Chris, I like that you don&#39;t discount a gluten...Chris, I like that you don&#39;t discount a gluten-free experiment just because you had a bad experience with it. It&#39;s easy to assume that your own experience will apply to everyone.<br /><br />Regarding panic and jitters in your experiment, could it have been caused by lack of magnesium? I&#39;ve read that insufficient Mg can cause these and other problems, but without a background in biochemistry, I don&#39;t know how good the science is. <br /><br />I do know that after I dropped wheat and started a low-carb diet, my swallowing problems came back and I had trouble with constipation. (But I felt so much better in so many other ways that I didn&#39;t consider returning to my old diet.) Both problems disappeared with Epsom salts or a big daily dose of a Mg supplement. Is it possible that humans need more Mg on a high-fat diet--or maybe it&#39;s just me?Lori Millerhttp://www.blogger.com/profile/02612141535162268390noreply@blogger.comtag:blogger.com,1999:blog-5977689274110133568.post-89391470577315443142011-01-08T09:40:46.373-08:002011-01-08T09:40:46.373-08:00Hi Chris, You&#39;re right, they say the cultures...Hi Chris,<br /><br />You&#39;re right, they say the cultures were prepared as in an earlier paper (http://www.ncbi.nlm.nih.gov/pubmed/1582589) which did cultures of biopsies with a peptic-tryptic digest of gliadin, but they don&#39;t show any data from that, they only cite the 2007 paper to support the gliadin upregulation of IL-15.<br /><br />The zonulin effects discussed here <a href="http://perfecthealthdiet.com/?p=873" rel="nofollow">http://perfecthealthdiet.com/?p=873</a> seem a lot more solid.<br /><br />The problems of epidemiological studies are great but China&#39;s cultural differences are helpful in this case. Whole swathes of the country are pretty nearly exclusive in the use of either rice or wheat. This is probably why the correlations between wheat or rice and health were the strongest in the study: the provincial aggregate data much more closely resembled the individual situation than for other foods.<br /><br />Unfortunately there&#39;s been a disturbingly small amount of research on food toxicity in general. A few researchers like Arpad Pusztai account for a large fraction of the literature on food toxins. When we searched the literature while writing our book it was hard to find molecular and cell biology papers on food toxins. Yet this is by far the largest source of toxin exposure for most people, as Bruce Ames points out.<br /><br />Best, PaulPaul Jaminethttp://www.blogger.com/profile/15122941682076992645noreply@blogger.comtag:blogger.com,1999:blog-5977689274110133568.post-7072847961473380882011-01-08T08:47:13.213-08:002011-01-08T08:47:13.213-08:00Hi Chris, Your response is much appreciated. The p...Hi Chris,<br />Your response is much appreciated. The problem generally is that &#39;traditional&#39; foods are not available. I don&#39;t make fermented vegetables, but I try to only give them shop bought sourdough bread and overall nutrient rich food. Even that bread is not perfect, as I gather, only the starter is fermented for a longer period and then they add the actual flour that sits together with the starter for a few hours.<br />The kids seem healthy, however my daughter has mild scoliosis and my son is shorter than the others for his age, although we are not of short stature. Their new permanent front teeth seem much bigger than the milk teeth and came on top of the old ones and will be maybe crowded. That remains to be seen. That&#39;s why I thought there might be a problem with vit D and minerals. (plus there are two cases of celiac in my husband&#39;s family, his aunt and her daughter and a case of alopecia areata, which could be an autoimmune disease linked to wheat)lightcanhttp://www.blogger.com/profile/03050215395108869677noreply@blogger.comtag:blogger.com,1999:blog-5977689274110133568.post-9789950882939666772011-01-08T08:14:20.174-08:002011-01-08T08:14:20.174-08:00snaider, I agree that my experience confounded GF...snaider,<br /><br />I agree that my experience confounded GF with CF. I can&#39;t remember for sure, but I was probalby using a verified casein-free ghee.<br /><br />ChrisChris Masterjohnhttp://www.blogger.com/profile/09922003080748568167noreply@blogger.comtag:blogger.com,1999:blog-5977689274110133568.post-58728065430259535022011-01-08T07:51:38.249-08:002011-01-08T07:51:38.249-08:00Paul, I saw that paper before writing my blog pos...Paul,<br /><br />I saw that paper before writing my blog post, but after perusing it, it did not seem relevant so I did not include it. I just perused it again, and I do not see anything relevant here. They stimulate IL15&#39;s receptor with IL15, not with gliadin peptides, and they report that &quot;No detectable levels of IL-15 were found in the non-CD patients.&quot;<br /><br />Paul, the China Study not only has no ability to suggest cause-and-effect as it is observational, but it is also an ecological study, which is widely considered the lowest level of epidemiological study. It&#39;s and excellent design for relating factors that occur at the group level -- say, correlating sizes of the national budget with tax laws -- but not so great for relating factors that occur in individuals.<br /><br />The work that Denise and others have done on wheat is important, but the take-home message from it will ultimately be that Campbell displayed enormous bias in ignoring a very strong correlation because it did not support his own hypothesis, while pursuing other correlations that supported his hypothesis but were much weaker. To read cause-and-effect between wheat and disease into it, beyond merely making a case that such a cause-and-effect phenomenon has some biological plausibility, would not be a proper use of the data.<br /><br />Perhaps wheat causes intestinal inflammation in most people -- but if so, good and properly interpreted research should be used to show that.<br /><br />ChrisChris Masterjohnhttp://www.blogger.com/profile/09922003080748568167noreply@blogger.comtag:blogger.com,1999:blog-5977689274110133568.post-45735738259931316552011-01-08T07:45:04.974-08:002011-01-08T07:45:04.974-08:00Hi Chris, I think the main reason because you got ...Hi Chris, I think the main reason because you got worse on GFCF is that you were missing some important nutrients.<br /><br />Dairy can be very healthy, did you eat ghee/clarified butter?snaidernoreply@blogger.comtag:blogger.com,1999:blog-5977689274110133568.post-8517980630216370922011-01-08T06:42:08.383-08:002011-01-08T06:42:08.383-08:00Hi Chris, Just thought I&#39;d add to Stephan&#39...Hi Chris,<br /><br />Just thought I&#39;d add to Stephan&#39;s link ... Bernardo et al followed the 2007 Gut paper with a much more extensive 2008 paper in Clinical and Experimental Immunology with better western blot data and, more importantly, PCR data of mRNA expression. The paper is <a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2561095/?tool=pubmed" rel="nofollow">here</a>.<br /><br />Our book cites both. I think the China Study results show that wheat consumption strongly correlates with poor health, and these papers show widespread inflammatory responses to it, so there&#39;s reason to believe that it will be health improving to avoid it.<br /><br />Best, PaulPaul Jaminethttp://www.blogger.com/profile/15122941682076992645noreply@blogger.comtag:blogger.com,1999:blog-5977689274110133568.post-22738566351161529992011-01-07T20:49:26.686-08:002011-01-07T20:49:26.686-08:00Responses to ...AL, Anonymous, and Imgenex. ...AL...Responses to ...AL, Anonymous, and Imgenex.<br /><br />...AL, I kind of get you, but I guess your hypothesis is kind of loosely formulated, and that&#39;s why I wasn&#39;t too clear on what you meant.<br /><br />Anonymous, I don&#39;t know that plant-free diets are harmful, but as far as I know, no human groups in the entire universe have ever eaten them, so I don&#39;t know why anyone would bother unless they find themselves hypersensitive to plant chemicals, or just really hate the taste or texture of plant foods.<br /><br />Imgenex, I&#39;m on facebook and twitter. You should be able to find me either place easily by searching my name. Glad you&#39;re enjoying the blog!<br /><br />ChrisChris Masterjohnhttp://www.blogger.com/profile/09922003080748568167noreply@blogger.comtag:blogger.com,1999:blog-5977689274110133568.post-24534250140105980232011-01-07T20:23:35.212-08:002011-01-07T20:23:35.212-08:00Really your post is very informative and I enjoyed...Really your post is very informative and I enjoyed your opinions. Do you use twitter or stumbleupon? So I can follow you there. I am hoping you post again soon.<br /><br /><a href="http://imgenex.com/" rel="nofollow">Interleukin</a>Imgenexhttp://www.blogger.com/profile/10042237812536700574noreply@blogger.comtag:blogger.com,1999:blog-5977689274110133568.post-58332235220232111922011-01-07T15:13:42.317-08:002011-01-07T15:13:42.317-08:00curious about your view of plant-free dietscurious about your view of plant-free dietsAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-5977689274110133568.post-62587005371103583532011-01-07T10:10:54.652-08:002011-01-07T10:10:54.652-08:00Trace metabolites aren&#39;t taught about in text ...Trace metabolites aren&#39;t taught about in text book bio-chemistry, but they are also doing things. My suggestion is that our individual genetics and environment (diet, emotions included) combine to make us influenced by trace metabolites - even if we are not 100% of the time showing any symptoms of them. <br /><br />Dietary habits are not free from long cycles of influence on us. We don&#39;t easily pick up those nuances because the process of nutrition seems like cause and effect are running the show. Since your reported type of annoyances were unpredictable, I suggest the trace metabolite derived from dopamine as your particular &quot;trickster&quot;. <br /><br />Why your dietary changes and re-incorporations of foods alleviated the episodes I am not sure of. If that was due to an epigenetic &quot;re-write&quot;, with full on histone acetylation changes opening up DNA for methylation programming, is not certain (to me).Might-o'chondri-ALnoreply@blogger.comtag:blogger.com,1999:blog-5977689274110133568.post-19661580382433977282011-01-06T19:05:42.378-08:002011-01-06T19:05:42.378-08:00Responses to Matt, lightcan, AND ...AL. Reply to ...Responses to Matt, lightcan, AND ...AL.<br /><br />Reply to Matt<br /><br />Hi Matt, I agree with you that in general the carbohydrate issue is confounded by total carb, gluten, and fructose. It is also confounded by processing, as processing methods that detoxify gluten have been abandoned in favor of processing methods that make flour more toxic. I agree that your call for gluten-free self-experiments will provide useful data for helping to sort this out, although some of the confounders will remain without additional experimentation with differently processed wheat products. Nevertheless, I think the important thing in the short-term is to identify toxic foods and get rid of them to allow healing, so I think what you&#39;re doing is good.<br /><br />On Crete, the traditional diet is based largely off wheat and dairy. Studies in the 1960s suggested their rate of myocardial infarction in men over the age of 45 was 0.7%. See here http://www.ncbi.nlm.nih.gov/pubmed/14263030 . There was a somewhat higher rate of murmurs that were considered possible evidence of arrhythmia due to aortic atherosclerosis (7-8%), but they also had a very high rate of smoking -- 55% of the men smoked and 35% smoked more than a pack per day. I think these numbers are pretty impressive and consistent with their wheat-based diet being most likely healthy for them.<br /><br />There may be other examples. It&#39;s difficult to say, because heart disease has not been studied with any rigor until the modern era, when the spread of wheat has occurred in the form of a global spread of white flour and sugar. Even worse, during the first half of the century when this spread was rapidly initiated, wheat was treated with nitrogen trichloride, which created toxic inhibitors of biosynthesis of glutamine and glutathione and led to hysteria in dogs. It was abandoned in US and UK due to concerns of potential human hysteria and in Canada because it was explosive and thus a risk to mill workers. Trying to tease out all these factors using a historical or epidemiological worldview would be incredibly difficult, so we need rigorous science in the form of publication-worthy literature, self-experimentation, and careful clinical practice. Thanks for being part of the solution!<br /><br />Reply to lightcan<br /><br />lightcan, you&#39;re welcome. I think if your kids are healthy, you are healthy, and there are no signs of disease, than not worrying about it is much, much, much healthier than worrying about it. I would just feed foods traditionally prepared that make you and your family feel well. I would not feed toxic white flour junk foods, of course, but if long-rise breads, preferably of older varieties if you can find them, seem health-promoting and there are no signs otherwise, I think you are in good shape.<br /><br />I will post more on Orthodox fasting in the future. Briefly, I would suggest emphasizing shellfish, coconut products, fruits, and fermented vegetables. If you tolerate them, leafy greens like cruciferous vegetables are a great idea for calcium. Red palm oil is a good idea for vitamin A. Bananas are one of the best plant sources of B6. And spinach, while its calcium is poorly bioavailable, and while it is a source of oxalate (that should be tolerated by most people due to its high calcium content), is an excellent source of betaine that can substitute for the choline missing from egg yolks and liver. Hope that helps!<br /><br />Reply to ...AL<br /><br />...AL, I kind of follow you but can&#39;t quite tell what your conclusion is. I have a suspicion, with a very small amount of evidence, that elevated levels of histamine in the brain can contribute to panic attacks, and the rate-limiting step of histamine detoxification is methylation, so it makes sense that foods rich in folate, B12, choline, and betaine would help. Wheat does have quite the mega-dose of betaine, although clearly liver and egg yolks are king here.<br /><br />ChrisChris Masterjohnhttp://www.blogger.com/profile/09922003080748568167noreply@blogger.comtag:blogger.com,1999:blog-5977689274110133568.post-22664863921785635132011-01-06T11:09:44.874-08:002011-01-06T11:09:44.874-08:00Go back with me, if you would, to Chris&#39; enigm...Go back with me, if you would, to Chris&#39; enigmatic &quot;periodic jitters&quot;, &quot;panic attacks&quot;. Grain carbohydrates are usually feel good foods, they involve dopamine neuro-biology. <br /><br />After dopamine is put into play the enzyme catechol-o-methyl-transferase (COMT) outside the cell renderes the mono-amine metabolite 3 meth-oxy-tryramine. This works on us extra-cellularly even at trace concentrations.<br /><br />Although it is not a proper dopamine pathway tryramine is it&#39;s own neuro-transmitter. It is involved in emotions, heart regulation (as in panic attack), abnormal involuntary tweaks (dyskinesia, as in jitters) and hyper/hypo activity.<br /><br />The enzyme catechol-omethyl-transferase (COMT) is involved in tyramine processing. If this enzyme is inhibited, due to the number of genetic copy numbers or diet, then the metabolite meth-oxy-tryamine level is low. <br /><br />If the enzyme mono-amine-oxidase (MAO) is inhibited, due to the number of genetic copy numbers or diet, then the same metabolite level is high. It too is integral to the pathways under discussion. <br /><br />COMT goes on to activate our trace amine associated receptor (TAAR1 in this case). Humans have 9 genes for these receptors. An individual response is what occurs from fluctuations of trace concentrations of that dopamine metabolite.Might-o'chondri-ALhttp://www.blogger.com/profile/17572208303795253605noreply@blogger.comtag:blogger.com,1999:blog-5977689274110133568.post-6479729610962178112011-01-06T09:46:21.111-08:002011-01-06T09:46:21.111-08:00Thank you, if there are no symptoms of celiac, no ...Thank you,<br />if there are no symptoms of celiac, no point in having a biopsy. The problem is I don&#39;t know how does the disease develop, what are the first symptoms. It depends on so many things. At the moment I can think of nutrient malabsorption in the case of my children but there is no clear evidence. I give them vit D.<br /><br />Could you maybe in the future write about greek orthodox fasting again suggesting some meals? I am a bit short of ideas for Lent as the people I know, including monks, would base their meals on dry beans, bread, polenta, vegetables and potatoes.lightcanhttp://www.blogger.com/profile/03050215395108869677noreply@blogger.comtag:blogger.com,1999:blog-5977689274110133568.post-2000991950342033532011-01-05T23:44:17.267-08:002011-01-05T23:44:17.267-08:00Chris, Thanks for posting this. I have not closed...Chris,<br /><br />Thanks for posting this. I have not closed my mind to the possibility that gluten is not the major player in the decline of health for everyone. I am fairly certain that there are many people suffering because of it - undiagnosed celiacs or people with gluten allergies, but they may not represent the majority. <br /><br />The way I see it, there are a lot of factors that confound the issue. Is it gluten, fructose, or over consumption of carbs that are the cause of the problem? How are they related? Does gluten cause carb intolerance? Does fructose cause gluten intolerance? Does a low-vitamin and mineral carb diet lead to problems with gluten and fructose? <br /><br />It&#39;s a mess since gluten = carbs and fructose = carbs. <br /><br />The reason I chose to focus on gluten is that we have the Kitavans and others that seem to thrive on carb heavy diets. I know of no culture that has done well with wheat. Of course, fructose has been around forever, but not in the levels we see it today. <br /><br />It just seemed to me that gluten was the most likely factor. So I browbeat a bunch of people to go without it for a month and am waiting to see what happens.Matt Lentznerhttp://www.blogger.com/profile/12510000649043210096noreply@blogger.comtag:blogger.com,1999:blog-5977689274110133568.post-43989660513722903312011-01-05T20:55:54.069-08:002011-01-05T20:55:54.069-08:00Responses to Roland, Todd, Mario, Sam, lightcan, A...Responses to Roland, Todd, Mario, Sam, lightcan, Anonymous, Eric, Daniel, Mike, John, Stephan, and ...AL.<br /><br />Hey Roland, A month might not always be enough time, but if you don&#39;t have any problems you&#39;re trying to resolve, I doubt it&#39;s worth trying longer. I once took seriously the claim in _Dangerous Grains_ that the first sign of gluten sensitivity might be cancer. Upon reflection, the very nature of the claim makes it almost impossible for there to be evidence of it. I&#39;m glad my posts are helpful, and you&#39;re welcome!<br /><br />Todd, the main reason would be not getting enough of a certain nutrient or set of nutrients. For some people, including myself, restrictive diets also make it sometimes hard to get enough calories. <br /><br />Mario, yes, I think that is a good reason why it is a worthwhile personal experiment, and why such an experiment is much better than getting a test of dubious value.<br /><br />SamAbroad, I don&#39;t eat a lot of wheat. I do have a grain grinder and will grind spelt or other grains if I make my own grain. I tend to buy French Meadows European Style 100% Rye Bread more often, which is not very good untoasted but is quite delicious toasted and butterred. Dr. Davis impresses me very much as a clinician and I find his blog very useful, but I&#39;m not very impressed with his experimental techniques. I think it is possible that wheat is atherogenic but I don&#39;t think he has provided much evidence of this.<br /><br />Lightcan, anti-tTG antibody is an important part of the blood test for celiac, but it misses a small but substantial portion of people who would be caught on biopsy. If there are strong symptoms of celiac, biopsy should be done even in the presence of a negative blood test. It is possible that some people who are not celiac are gluten sensitive, and indeed there are a lot of anecdotes supporting this, so trying gluten-free and looking at the results is useful.<br /><br />Anonymous, it&#39;s possible but &#39;if it ain&#39;t broke don&#39;t fix it&#39; might be useful to apply here. What kind of diet makes you feel best?<br /><br />Eric, you&#39;re welcome!<br /><br />Daniel, good points.<br /><br />Mike, good points. I wrote about that Neanderthal study in my review of Perfect Health Diet: https://www.cholesterol-and-health.com/Paul-Shou-Ching-Jaminet-Perfect-Health-Diet-Review.html And Melissa also wrote about it here: http://huntgatherlove.com/content/neanderthal-diets-included-some-grains<br /><br />John, thanks for the references. My macronutrient intakes were pretty balanced I think, and I don&#39;t have hard evidence cortisol was involved. But I do find that carbohydrates provide a calming effect and I often feel wired without enough of them.<br /><br />Stephan, thanks for sending the paper along. For the sake of others, it looks like this paper provides some evidence that high doses of gluten could be harmful for first relatives of celiacs. The enzyme paper said the enzyme was active at pH 3-8 and they suggested these enzymes are likely to be produced after the mouth as well. Just because an enzyme becomes inactive in certain parts of the stomach does not mean it gets permanently denatured. I think it is possible that these act both before, in certain parts of, and after the stomach. In any case, in non-celiacs there is evidence I cited that both these peptides are completely degraded intracellularly. All that is necessary to make my point, though, is to demonstrate the plausibility of variation in digestion, so as to communicate part of the need for an in vivo study.<br /><br />...AL, very good points. Chewing long almost certainly helps digestion and maybe helps with this, although as I noted above I think these enzymes are likely to be active outside the mouth.<br /><br />ChrisChris Masterjohnhttp://www.blogger.com/profile/09922003080748568167noreply@blogger.com