Saturday, November 27, 2010

Does Choline Deficiency Contribute to Fatty Liver in Humans

by Chris Masterjohn

I hope all of those who celebrated had a wonderful Thanksgiving!  Giving thanks is at least as healing as a healthy diet!  For those of you who celebrated it just to eat a lot or for entirely other reasons, I hope you also had a wonderful holiday, and for those of you who did not celebrate anything at all, I hope you had a wonderful weekend.

In my last choline post, I presented my hypothesis that a suboptimal intake of choline, found most abundantly in egg yolks and organ meats like liver, is the preeminent cause of fatty liver disease. This disease may afflict 70-100 million Americans.  If you missed it, you can find the post here:

The Sweet Truth About Liver and Egg Yolks -- Choline Matters More to Fatty Liver Than Sugar, Alcohol, and Fat

After reading the research reviewed in that post, I'm quite convinced that the development of fatty liver is pretty simple: anything that increases the amount of energy that the liver needs to process forms the first part; anything that impairs the ability of the liver to export that energy forms the second part. High intakes of total calories, sugar, fat, or alcohol can all contribute to fatty liver in animals.  But the king of all nutrients needed to export that energy as fat, choline, protects against the disease in all of these animal models.

Of course, a high intake of PUFA contributes to the inflammatory component, and when combined with other toxic factors may also contribute to the fatty component by preventing the liver from exporting its fat.

Does choline play the same role in fatty liver disease in humans?  There are a few reasons to think it does.  The most convincing of these is that it's been demonstrated in folks getting fed intravenously. The most interesting of these is the wide prevalence of a defect in the gene that allows us to synthesize phosphatidylcholine from the amino acid methionine.  Its prevalence is high in the general population but almost complete among those with fatty liver.

The basic mechanisms of fatty liver in humans are the same as they are in animals.  Humans with fatty liver disease have increased lipogenesis (synthesis of fat from carbohydrate) (1), increased circulation of fat released from adipose tissue (2), and decreased secretion of fat from the liver (3).

Although folks with fatty liver release more fatty acids from the fat tissue, the studies cited above show that their livers don't actually synthesize more fat from these fatty acids than the livers of healthy folks do. So those fatty acids may contribute to "lipotoxicity" -- and in fact the creation of triglycerides in the liver is in part probably an effort to protect against the toxicity of excess free fatty acids -- but it seems that the synthesis of fat from carbohydrate is more important than the release of fat from adipose stores.

The increased synthesis of fat almost certainly means that the burning of fat is decreased, because these two phenomena are metabolically linked to each other.  Animal experiments using specific enzyme inhibitors suggest that both need to occur simultaneously to get significant increases in liver fat (4), if you want to induce it without any changes in the diet.

It was until quite recently thought that choline is not an essential nutrient in humans because choline can be synthesized from methionine. In 2001, however, a very small randomized, placebo-controlled trial conducted in 15 patients who developed fatty liver while receiving intravenous total parenteral nutrition (TPN) showed that the addition of two grams of choline chloride to the formula could completely resolve the fatty liver (5).

There are a number of other nutrients that reduce our requirement for choline in addition to methionine.  One is betaine, which occurs most abundantly in wheat, spinach, and beets.  Folate and vitamin B6 are also important.  However, betaine, folate and B6 simply spare choline. We can actually use methionine to methylate a phospholipid called phosphatidylethanolamine to phosphatidylcholine, the principal choline-containing phospholipid.

There's just one problem: doing so requires an enzyme called phosphatidylethanolamine-N-methyltransferase (PEMT).  The presence of at least one defective copy of this gene is extremely prevalent in the population, and it dramatically raises our chances of developing fatty liver on a low-choline diet. 

Here's what one case-control study found when they compared the prevalence of the defective gene among people who had fatty liver and those who didn't (6):



The vast majority of people in this study had at least one defective copy of the gene, but almost everyone who had fatty liver had at least one copy. The difference between the two groups doesn't seem huge, but if we spin the tables and look at who didn't have any copies of the defective gene, which is just another way of looking at the same data, the difference looks pretty big:



And here's the prevalence of people with two copies of the defective gene:


Of course "defective" is a value judgment.  Apparently it's "good enough" to survive at a high prevalence.  But I'll call it "defective" for now for the sake of simplicity.

One recent study suggests that people with defective copies of this gene are much more vulnerable to developing fatty liver on a low-choline diet. 

The study is built on the findings of a previous study published a few years ago, so we'll discuss that one first. In the first study (7), the investigators fed 57 healthy men and women a diet containing roughly the RDA for choline (550 mg choline for every 70 kg bodyweight) for ten days.  Then they switched them to a choline-deficient diet for 42 days.  The diet was adequate (meeting or exceeding the RDA) for the other essential nutrients but contained less than 50 mg choline for every 70 kg bodyweight.  The investigators then increased their choline intake stepwise, replacing 25% of it for ten days, then 50% for another ten days, then 75% for ten days, and then 100% for the final ten days.

38% of young women, 40% of men, and 80% of postmenopausal women developed fatty liver.  81% of these people resolved their fatty liver at some point during the repletion phase, while the others recovered only after returning to a normal diet.

This study is not terribly convincing.  It is essentially an observational study because there was no control group, and rather than giving different people different doses of choline during the repletion period, they all got the same dose at once, increased over time.  The results could be explained in numerous alternative ways.  For example, the low-choline diet could have had some noxious factor in it that the subjects adversely reacted to at first, but to which most of them adapted over time. 

Nevertheless, the study is an interesting pilot study, and it suggests that there may be very wide variability in the choline requirement, and that it may be much higher than the RDA in some people.  And these people were healthy.  As indicated by the genetic data above, people with fatty liver disease -- possibly a third of the population -- might have even higher needs for choline.  And of course, the whole point of my last choline post was that the choline requirement is affected dramatically by what else we eat, not just our genes.

The second study (8) was designed similarly, but they did not monitor variation in the amount of choline needed for repletion.  In this study, they divided postmenopausal women into those who had defective copies of the PEMT gene and those who did not, and they randomly allocated half of them to estrogen therapy.  After all, the fact that twice as many postmenopausal women developed fatty liver in the previous study compared to younger women suggests that estrogen might reduce the choline requirement.

The results are pretty remarkable.  The following results are for "organ dysfunction," which included fatty liver, elevated liver enzymes, or signs of muscle dysfunction, but 90% of the women who developed "organ dysfunction" were diagnosed on the basis of fatty liver.  The PEMT gene had a huge influence on who developed fatty liver:


In the placebo group, only 25% of women with no defects in the PEMT gene developed "organ dysfunction" on the low-choline diet, but a whopping all of them developed organ dysfunction, virtually all of which was fatty liver, if they had at least one copy of the defective gene!

The estrogen had a remarkable protective effect.  Two copies of the defective gene was very rare in this population (since the inclusion criteria required the participants be healthy), and no one was represented in the estrogen group. Nevertheless, even having one copy of the defective gene has a remarkable effect, as we'd expect based on the above graph:

Quite an interaction!  The combination of estrogen and two healthy copies of the PEMT gene abolishes the risk of choline-deficiency associated fatty liver, at least in the short course of a month, on an otherwise adequate diet.  But it seems those with two of the "good" copies are in the minority.

The authors made the following remark about the effect of estrogen:

It makes sense, from an evolutionary perspective, that young women can supply more of their choline requirement from endogenous biosynthesis because pregnancy and lactation are times when the demand for choline is especially high, particularly to support the developing nervous system.
That's a rather odd comment considering the paper made no attempt to unravel the gentic mechanisms by which estrogen is increased during youth or by which estrogen decreases the choline requirement, but it's an interesting tangent.  Certainly, it is biologically more important to provide choline to the brain of a developing fetus and infant than it is to make enough to get the fat out of your liver. 

On the other hand, men were a lot better off than postmenopausal women, and although it's possible for men to lactate, it's very rare. 

Evolutionarily, it makes a lot of sense for men not to lactate, because... ah well, nevermind.  Maybe in another post.

Neither of these studies provide conclusive evidence that suboptimal intakes of choline cause fatty liver in humans, but together the totality of these data make a strong case for testing the hypothesis.  It certainly seems that most of us are vulnerable to needing choline, rather than just methionine and the other nutrients that spare it. The TPN study provides proof of principle that choline does indeed reverse fatty liver in humans. And the universality of the protective effect of choline in diet-induced animal models of fatty liver certainly puts choline at center stage.

PEMT is not the only gene that affects the choline requirement.  I'll be writing much more about the choline requirement and how to obtain it in a future post, and that will cover the effects of other genes as well.

Lets raise another glass to King Choline!  Long live liver and eggs!

Read more about Chris Masterjohn, PhD, here.

171 comments:

  1. I wonder where high-carb eaters like Kitavans and Papua New Guineans etc get their choline from. Maybe Stephan could do a round-up post on high carb cultures and guesses about their choline sources.

    I wonder how prevalence of PEMT varies with latitude, or otherwise with geography. High PEMT incidence may indicate high levels of traditional choline consumption (eg organ meats -- you should mention kidney and brain as other sources!) and/or low-ish carb consumption, although in your last post you did leave long chain fats on the hook as well.

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  2. Its often said that Milk thistle (or in supplement form: liposome encapsulated silibinin and silymarin), is good for the liver. Any truth to that? Can it actually reverse and repair liver damage?

    ReplyDelete
  3. Thanks for this series. Even as a layperson, I'm finding it really fascinating.

    One comment. If you're ever so inclined, I'd be really interested to hear your thoughts on something I've been noodling about re the liver and obesity, which is:

    diet -> liver injury -> obesity & metabolic syndrome

    Peter@Hyperlipid started me down this path via this post: http://high-fat-nutrition.blogspot.com/2010/03/getting-fat-is-good-official.html (my take is here: http://weightmaven.org/2010/03/14/obesity-cause-or-symptom/)

    I had mostly been thinking of the things in the diet as the culprits (fructose, omega 6s, refined grains). But perhaps it is also things missing from an industrial diet (e.g., choline) that also contribute. Hmmm!

    ReplyDelete
  4. Responses to Ed, Anonymous, and Beth.

    Ed, I wonder also. However, Stephan indicated that they likely consumed additional foods away from the camp, and perhaps these were whole insects and other organ-rich foods. Maybe some of their foods are very high in betaine. I agree that the PEMT polymorphism could be a marker for diets traditionally high in organ meats. In any case, it's pervasive here.

    Anonymous, milk thistle raises glutathione. I'm not sure where it ranks out of the multitude of plants that contain beneficial toxins that increase glutathione levels. Subject of a future post for sure, but lower priority than choline, fructose, AGEs and a few other things right now.

    Beth, I agree without doubt that the formation of triglycerides is protective against toxicity lying downstream from fatty acids. I also agree that liver damage is likely to lie behind poor glucose metabolism. As indicated several posts ago, insulin almost certainly does not in and of itself make people fat. Very soon I'll have a post on how I think liver damage may contribute to leptin resistance and thereby to obesity.

    Although I agree that the formation of triglyceride is protective, I disagree that obesity is protective. I think that obesity most likely results from leptin resistance and a resultant dysregulation of energy intake and output.

    Poor use of a psalm.

    Chris

    ReplyDelete
    Replies
    1. I had my gall bladder taken out. I have fatty liver. I think someone may have seen it years ago, as I was once asked during a liver sonogram if I drank alot. Wondering now if they saw scirosis type damage due to fatty liver. I too was told about milk thistle. I am not a diabetic but close. I have tried life changes like vegan/vegetarian non gmo, no PUFA and need to lose half of me. I have thought alot was due to poor working liver. I'm now reading on leptin and learning to want to exercise. Thanks for the info

      Delete

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      During the first year, I had faith in God that i would be healed someday.This disease started circulating all over my body

      and i have been taking treatment from my doctor, few weeks ago i was searching on the internet if i could get any

      information concerning the prevention of this disease, on my search i saw a testimony of someone who has been healed

      from HERPES SIMPLEX-2 by this man Dr Agbaka and she also gave the email address of this man and advise we should

      contact him for any sickness that he would be of help, so i wrote to Dr Agbaka telling him about my (HERPES Virus) he

      told me not to worry that i was going to be cured!! hmm i never believed it,, well after all the procedures and remedy

      given to me by this man few weeks later i started experiencing changes all over my body as the Dr assured me that i

      will be cured, after some time i went to my doctor to confirmed if i have be finally cured behold it was TRUE, So friends

      my advise is if you have such sickness or any other at all you can email Dr Agbaka on : agbakaherbalhome@gmail.com

      OR call and watsapp him on his cell phone: +2348077126783. Sir i am indeed grateful for the help, i will forever

      recommend you to my friends!!!

      Delete
  5. Oh also Ed, they derived most of their calories from glucose. Glucose is perhaps the least likely of macronutrients to increase liver fat and thus need for choline. In fact, everything I've been saying about the increased need for choline with fat, fructose, and ethanol has been considered relative to intakes of glucose.

    Chris

    ReplyDelete
  6. Hi Chris.

    One reason why I think this may be a huge discovery is that it could explain the various dietary "paradoxes" that are often invoked to question the effectiveness of specific diets.

    The paradoxes that I refer to are diets that supposedly promote health and longevity because of presence/absence of certain foods, which eventually are found in other diets that also promote health and longevity.

    Having said that, do you think that choline deficiency can explain the various paradoxes that are out there? One thing that comes to mind is the old Loetschental Valley in Switzerland, studied by Weston Price. Its inhabitants apparently lived chiefly on rye bread and raw milk cheese.

    ReplyDelete
  7. Oops, my comment above came out wrong. I meant to describe something that like the French diet, which includes white bread, and still seems to promote longevity.

    ReplyDelete
  8. Ned, yes, I think it has the capacity to resolve many paradoxes. Principal among them so far is fat and fructose. Part of the reason, I believe, that high-fat diets cause problems in rodents is because the AIN-93 diets do not contain enough choline to deal with 30% fat, never mind 60% fat. Dietary fat, even "good fat," may promote disease in humans if not accompanied by sufficient choline.

    However, you bring up the most interesting paradox of all. Wheat is an EXCELLENT source of betaine, so much so that even white bread is a decent source, and betaine spares choline. Thus the traditional diet of Crete seems protective of heart disease and consistents almost entirely of wheat and dairy products. Or, as you say, even the French tolerate some white bread. More on this in my meeting-the-choline-requirement post.

    Chris

    ReplyDelete
  9. As given:
    (a) metionine amino acid is "substrate" for PEMT enzymatic conversion into choline for important liver function.
    (b) there is genetic variable for degree of PEMT enzyme functioning for choline synthesis
    Assume:
    (a) Methionine may be building up in many individuals
    Consider:
    (a)recent calorie restriction research indicates Methionine's relatively reduced intake may be important factor in benefits from under-eating
    (b)deduction is that those without manner of "shifting" methionine into choline may be benefited by reducing methionine; regardless of dietary calorie restriction
    So:
    (a) the "drag" of under utilized methoinine on the body may mean that choline's benefit for "fat" metabolism is only part of the picture
    Finally:
    (a) will post some about Betaine shortly

    ReplyDelete
  10. Mitochondri-AL,

    I agree with you, but methionine in excess of what can be used by PEMT actually increases the choline requirement, so I think your observations integrate nicely into the very simple hypothesis I'm presenting, rather than urging for a more complex explanation.

    I am not suggesting that the explanation has no more complexity; however, I think the accumulation of fat can be very simply explained in terms of this equation:

    fat accumulated = (fat in + fat created) - (fat exported)

    And that choline's overwhelming role here is simply to export the fat. Much of the complexity added to the picture of steatosis itself (again, putting aside the issue of progression to steatohepatitis) is probably downstream of this. For example, this accumulation plus associated compromise in triglyceride formation could result in oxidative stress and/or inflammation, the latter of which contributes to more oxidative stress, which would further decrease triglyceride output. However, noting every complexity is is important to do somewhere, but it's also important to present a simpler "big picture" when all of the pieces fit together into that big picture nicely.

    Chris

    ReplyDelete
  11. Does sprouted wheat contain betaine? I eat Food For Life sprouted grain breads on occasion and have been wondering if even fully sprouted/fermented breads like that are still problematic, even in small amounts like 1 slice per day. I know you could live without grains and many people actually have to, but I find it to be a very effective vehicle for a couple tablespoons of pasture butter or occasionally sprouted nut butters.

    Also, does Betaine HCI tablets count for the same thing regarding its effect on choline? Usually, a person would take the Betaine HCI tablets to increase stomach acid for improved digestibility (GERD/heartburn), but I wonder if there is also another benefit related to choline.

    -Jack Kronk

    ReplyDelete
  12. Betain:
    (a) is tri-methyl-glycine; so with 3 methyl is a "donor" to methylation pathways and source of amino acid Glycine
    (b) is water soluble
    (c) incidently, beneficially modifies homocysteine's behavior
    Methylation:
    (a) proteins' action at chromosomes are subject to way methylation (and acetylation) is going on in the cells
    (b)betaine "boosts" the methyl-transferase enzymatic synthesis of hypothalmic and pituitary NMDA (N-methyl-d-aspartate)
    Glycine amino acid:
    (a) it's receptors "mimic" GABA; acts to down regulate neuro-transmitters
    (b) counters damage to mitochondria; (other, etc., benefits not specified here)
    Choline relevance:
    (a) given = can "spare" Choline with betaine intake
    (b) traditional diets deficient in animal source of choline metabolized plant betaine (decreased their choline "requirement")
    (c) proposed: DNA methylation (thanks to betaine) increases pathway for "endogenous bio-synthesis" of choline when lack genetic PEMT enzyme &/or lack circulating dietary amino acid methionine for a substrate
    (d) curiously: methylation "ups" molecular interaction with fats; & cholesterol lipids are involved in hormone synthesis (mentioned regarding: less % fatty livers in traditional diets; & less fatty liver allows for more efficient function)
    Beets:
    (a) in the news for nitric oxide benefits, blood pressure & brain vaso-dilation
    (b) contains betaine; thus glycine & pro-methylation food
    (c) "Kvass" from beets benefit more complex than adage they are "good" for the liver because they have vitamins & minerals (finally, red color of beets is not from iron)

    ReplyDelete
  13. Reponse to Jack and Mitochondri-AL

    Jack, good questions. Yes, betaine HCl contains betaine. I will try to get data on betaine in sprouted wheat, if available, for my choline requirement post.

    Mitochondri-AL, it seems like you have a number of good points buried in your post, but it is difficult to understand what you are trying to say because you do not write in complete sentences.

    Chris

    ReplyDelete
  14. Mitochonri-AL, I don't know what happened to your post. Please repost it if you didn't mean to delete it. If you've lost it, I can repost it for you as I received it by email.

    Thank you for your response in sentence format.

    I agree that choline plays other important functions in the liver. The liver and kidney are the main organs that use betaine, which is derived from choline in the absence of major dietary betaine contributions. Betaine fulfills the same function there as B12/folate in regenerating methionine and then S-adenosyl-methionine (SAM) from homocysteine to continue the methylation process. That said, with sufficient serine and B6, the extra methionine will be converted to glutathione, which I think is the ideal situation. So, ultimately, I think consuming liver promotes the ideal of allowing choline to be used for its own sake and allowing B6 to be used for the generation of glutathione from methionine.

    I do agree that methionine can be harmful when it is not balanced by other nutrients such as folate, B6, B12, choline, and betaine. And even in this situation, the generation of glutathione is still using up serine, which is the main source of glycine. So I think it's also important to balance muscle meat with skin and bones, which are better sources of glycine.

    I made this point a couple years ago in my lecture and article on pregnancy nutrition:

    http://www.westonaprice.org/childrens-health/1380-vitamins-for-fetal-development-conception-to-birth.html

    So, I definitely agree with you on the potential harms of excess methionine if it isn't balanced by other amino acids and nutrients. Ultimately, however, the accumulation of liver fat still comes down to this equation:

    accumulated fat = (entered fat + synthesized fat) - (exported fat)

    I think that is axiomatic. And while I'm sure that excess methionine beyond the liver's capacity to process it might damage the liver's ability to export it's fat, the role of choline still is most obviously and directly connected in that it is required for phosphatidylcholine synthesis and thus VLDL secretion. So, without excluding other indirect possibilities, for now I'm highlighting the more obvious direct relationship.

    Thanks for your comments and please feel free to contribute more.

    Chris

    ReplyDelete
  15. I've read your posts on fermented soy, honey, insulin resistance, and choline, and they helped me a lot.

    Thanks.

    ReplyDelete
  16. Internet & I aren't fully sorted out.
    Please, do post my comment if you're able to.
    Thanx for feedback & your time spent on it.

    ReplyDelete
  17. Organism as a Whole, you're welcome and thanks!

    Might-o'chondri-AL and everyone else, below is ...AL's post, which somehow got eaten, to which I replied above.

    Chris

    ========

    Outline form,":", was to avoid long texts.
    The items in parenthesis,"(a)", "(b)", went to what subject word preceeded with a ":".
    ((If anyone is confused about an item I will write it out better. ))

    My comments are not an argument with your explanation.
    Curious that methionine excess "increases choline requirement" (despite PEMT enzyme limitation).
    Seems like the choline is doing another liver task in clearing high (for that individual) methionine; with body "demanding" choline.

    This suggests that high dietary methionine "must" be taken care of. (Research that "excess" methionine impinges on longevity dove-tails with the "demand" for additional choline to respond).

    You show the liver becoming fatty & functionally suspect when not enough choline at work. I posit there is also methionine accumulation possibly "threatening" the liver health.

    Allow the premise that traditional diets were less likely to provoke visceral (liver) fat. And that indications of fatty liver were seen in some elder segments when tested.
    Could the sparse, traditional diet
    fatty livers indicate methionine eventually might get "the better" of choline somehow ?
    And, is their inconsistent access to calories (no fridge, unsteady harvest from land or sea, etc.)a factor that prevented methionine becoming a burden ?

    All over the world people ate their version of a survival diet & some showed good health. Healthy livers are relevant.

    The betaine intake I tried to lay out is one factor for "less" fatty liver problems. Beet "Kvass" is a European take on over coming insufficient choline to tackle the methionine load.

    The dairy cultures offer some interesting examples of methionine intake. Cheese making involves the seperation of curd solids from the whey. Yogurt (as will any form of clabbering the curds & the whey - including Kefir "grains" and such as the Masai use of cow's neck blood) without refrigeration and stabilizers will visibly seperate.

    Point to note is that whey is high in methionine.This is what I find relevant to your discussion of fatty livers.
    Cheese eaters are not consuming that whey (except as Ricotta). Nor without refrigeration was fresh milk (with it's whey) a practical farm staple to lay up.

    Many cultures feed that methionine rich whey to fatten up their slaughter livestock. It may be the dietary methionine is implicated in their holding on to fat gains - they're getting fatty liver metabolism (& poor choline intake).

    Yogurt for Mediteraneans (Greeks, Lebanese, Israelli)is just a step before they strain out the whey. In pastoral Africa the heat seperates the whey & if no famine the nursing livestock gets fed the whey - to make up for what milk "stole" from her mother. India's cuisine was formed more around the "curd" semi-solids & "paneer" cheese. In the Caucasus Kefir was fermented in a jiggled animal pouch(they could decant off the whey & use it to fatten up their non-milking stock).

    Fatty liver incidence in modern cultures may be rising with choline being forced to deal with excess dietary methionine (among other things) & genetics of slack PEMT enzymes. Is this a chicken and the egg riddle?

    ReplyDelete
  18. This is from Jane Karlsson.
    ================================
    Hi Chris,
    I have a suggestion for you. The phenomena you describe may be due to copper deficiency. See for instance this recent paper 'A role for low hepatic copper concentrations in nonalcoholic liver disease', which says:
    'Reduced hepatic copper concentrations are found in human NAFLD and are associated with more pronounced hepatic steatosis, NASH, and components of the MetS. The development of hepatic steatosis and IR in response to dietary copper restriction in rats suggests that copper availability may be involved in the development of NAFLD.'
    http://www.nature.com/ajg/journal/v105/n9/full/ajg2010170a.html
    Copper deficiency depresses synthesis of phosphatidylcholine, according to Leslie Klevay's paper 'The effect of copper deficiency on heart microsomal phosphatidylcholine biosynthesis and concentration.'
    http://www.ncbi.nlm.nih.gov/pubmed/3028882
    It seems that copper deficiency affects both pathways of PC synthesis. Your reference 10 says that the inhibitory effect of choline deficiency on VLDL secretion can be compensated by the methylation of phosphatidylethanolamine. This would need copper, because methylation reactions are controlled by the copper enzyme S-adenosylhomocysteine hydrolase.
    http://onlinelibrary.wiley.com/doi/10.1002/neu.20114/pdf
    Synthesis of methionine by methionine synthase is also reported to require copper as well as vitamin B12.
    Some more points:

    Oestrogen may protect by increasing copper transport
    Fructose may be bad because it causes copper deficiency
    Hepatic iron overload is associated with fatty liver and is caused by copper deficiency
    Saturated fat does not cause heart disease in rats if they are given extra copper
    and finally, 'EFA deficiency' may actually be copper deficiency, because copper is needed for fatty acid desaturases.
    http://onlinelibrary.wiley.com/doi/10.1002/jsfa.2740280115/pdf
    Regards,
    Jane

    ReplyDelete
  19. This comment has been removed by the author.

    ReplyDelete
  20. Nice concise copper comment; like it. Before anyone takes a mega-supplement remember genetics.

    Globally millions have a genetic trait to excessively take up copper into their liver cells. That build up is, shall we say, undesireable.

    ReplyDelete
  21. Chris,

    If I didn't miss it, you have not mentioned this pilot study which I think validates your recent choline-fatty liver series.
    http://www.ncbi.nlm.nih.gov/pubmed/11569700

    ReplyDelete
  22. Great post, Chris! I can see you have put in a lot of research into this. I am not very familiar with choline deficiency but I'd have to ask whether a fatty liver could cause hypertension. I asked because I can see people who are underweight and yet their blood pressure are higher than normal.

    ReplyDelete
  23. I'm really fascinated by everything in this blog, thanks to all who've contributed. My query regards the use of whey powder in nutritional protocols to increase protein intake. Could methionine from whey be increasing the risk of fatty liver (and therefore undermining the protocol in its entirety) if measures aren't taken to ensure commensurate additional quantities of choline through the diet?

    ReplyDelete
  24. In light of this study: http://ajcn.nutrition.org/content/early/2012/02/14/ajcn.111.020156
    Does your conclusion about choline and fatty liver still hold?

    ReplyDelete
    Replies
    1. Hi Stu,

      Based on the abstract, I don't see how it could affect my conclusion. I don't think the absolute amount of choline in the diet is a major contributor to fatty liver, but diets that contribute to greater energy flux as fatty acids and triglycerides through the liver probably require more choline to deal with it. So, I don't think it's very helpful to just look at choline intake by itself.

      Chris

      Delete
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      Delete
  25. Fatty liver is surely a major problem, a lot of people face issues related to it, choline deficiency might contribute to fatty liver, egg yolks can be very helpful in this situation.

    ReplyDelete
  26. How about supplementing with a little TMG?

    ReplyDelete
  27. Why don't people with fatty liver try supplementing for 6 months to a year, with a choline supplement such as choline bitartrate or choline citrate (lecithin is not a good source,btw) and report back their liver function findings here? might be interesting.

    ReplyDelete
  28. Chris --
    Can you recommend a Choline supplement that does not contain eggs or soy?
    My daughter is allergic to both and I can't get her to eat liver.

    Thanks.

    ReplyDelete
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  51. My Name are Nunu Caligril i am really happy that i was cured, form (HERPES SIMPLEX VIRUS) with the using of herbal medicine of Dr EDE-MEME , i have been suffering from this disease for the past 3 years without solution until i came across the email of this herbal man who have cure so many people with his herbal medicine, i also choose to give him a chance to help me and my husband, he told me what to do and i kindly did it, and he gave us his herbal medicine and direct me on how to use it, i also follows his instruction for use and he ask us to go for a check up after 7 days and which i did, to my greatest surprise our result came out as negative, we are really happy that there is someone like this DR.EDE-MEME who is ready to help anytime any day. to all the readers and viewers that is doubting this testimony stop doubting it and contact this Doctor and see if he will not actually help you. i am not a stupid woman that i will come out to the public and start saying what someone have not done for me. he is really a great man contact him now. with this email: edeharbelhome@gmail.com he is waiting for your email: edeharbalhome@gmail.com

    ReplyDelete
  52. My Name are Nunu Caligril i am really happy that i was cured, form (HERPES SIMPLEX VIRUS) with the using of herbal medicine of Dr EDE-MEME , i have been suffering from this disease for the past 3 years without solution until i came across the email of this herbal man who have cure so many people with his herbal medicine, i also choose to give him a chance to help me and my husband, he told me what to do and i kindly did it, and he gave us his herbal medicine and direct me on how to use it, i also follows his instruction for use and he ask us to go for a check up after 7 days and which i did, to my greatest surprise our result came out as negative, we are really happy that there is someone like this DR.EDE-MEME who is ready to help anytime any day. to all the readers and viewers that is doubting this testimony stop doubting it and contact this Doctor and see if he will not actually help you. i am not a stupid woman that i will come out to the public and start saying what someone have not done for me. he is really a great man contact him now. with this email: edeharbelhome@gmail.com he is waiting for your email: edeharbalhome@gmail.com

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  53. Good day to you all friends, my name is Kelly John from United State,I have been suffering from (HERPES) disease for the last four years and had constant pain, especially in my knees. During the first year,I had faith in God that i would be healed someday.This disease started circulate all over my body and i have been taking treatment from my doctor, few weeks ago i came on search on the internet if i could get any information concerning the prevention of this disease, on my search i saw a testimony of someone who has been healed from (Hepatitis B and Cancer) by this Man Dr OCUSODO and she also gave the email address of this man and advise me to contact him for any sickness that he would be of help, so i wrote to Dr OCUSODO telling him about my (HERPES Virus) he told me not to worry that i was going to be cured!! hmm i never believed it,, well after all the procedures and remedy given to me by this man, few weeks later i started experiencing changes all over me as Dr OCUSODO assured me that i have cured,after some time i went to my doctor to confirmed if i have be finally healed, behold it was TRUE, So friends my advise is if you have such sickness or any other at all you can email Dr OCUSODO on : (drocusodospellcaster@gmail.com) OR (drocusodospellcaster@yahoo.com) call him with +2348105578036 .. THESE ARE THE THINGS Dr OCUSODO CAN ALSO CURING OF GENITAL WARTS,GONORRHEA, HIV/AIDS , LOW SPERM COUNT, MENOPAUSE DISEASE, PREGNANCY PROBLEM, SHORTSIGHTEDNESS PROBLEM, STROKE, Bring back ex lover or wife/husband....sir i am indeed grateful for the help i will forever recommend you to my friends!!!

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  54. I can’t believe this. A great testimony that i must share to all patient of [HBV] in the world. i never believed that their could be any complete cure for HEPATITIS B or any cure for HEPATITIS B,Mrs aleac introduce me to Dr Aloma a herbal doctor who lives in south Africa who brought him back to life again.so i had to try it too and you can,t believe that in just few weeks i started using the herbal medicine he sent to me i was perfectly OK and . Right now i can tell you that few months now i have not had any symptoms of HBV and i have just went for text last week and the doctor confirmed that there is no trace of any HBV in my body system. Glory be to God for leading me to this genuine Dr Aloma I am so happy as i am sharing this testimony. My advice to you all who thinks that their is no cure for HBV that is Not true ,just contact him and get cure from Dr Aloma via his email (dralomaherbalcure@outlook.com(dralomaherbscure@gmail.com) and you will be free and free forever, Try it and you will not regret it because it truly works. One thing i have come to realize is that you never know how true it is until you try…or you can still call +2348051095232

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  55. My name is Prudence Oliver and am commenting this from Manchester City.
    DR Bude is the only Dr who could ever get my Herpes cured with his healing herbs, i have tried almost everything but i couldn't find any solution on my disease, despite all these happening to me, i always spend a lot to buy a herpes vaccines and drugs from hospital and taking some several medications but no relieve, until one day my friend came to visit me here in Manchester City, I told about my pains and she told me she had a Dr who helped her cure her herpes and she gave me Dr Bude Email dr.bude_cure_and_herbal_solution@hotmail.com , sometime i really wonder why she called him Father, i never knew it was all because of the great and perfect work that he has been doing that is causing all this. So i quickly contacted him with the email she gave me, and he ask me some few questions and he said a thing i will never forget that anyone who contacted him is ! always getting his or her healing. so i was amazed all the time i heard that from him, so i did all he asked me to do, he prepared the herbs and sent it to me< and instructed me on how to use them, I started using the herbal medicine and I was so surprised that after 6 days of using the herbal medicine i was healed, all the strength that has left me before rushed back and i becomes very strong and healthy without purses on my private part, this disease almost killed me, The Doctor also asked me how it happened and I told him how Dr Bude has helped me with the herbal medicine. i am very amazed and happy about the healing Dr Bude, gave to me, you can email him now for your own healing too at: dr.bude_cure_and_herbal_solution@hotmail.com

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  56. Hello viewers..i don't just know the reason why some people are still finding it difficult to believe that there is no cure for Herpes virus i have been Herpes since last six years,and my doctor say there is no cure for herpes and anyone that will say herbal medicine can cure herpes is lies,then discus with a friend of mine who was once troubled with herpes disease,he told me it a lie that herbal medicine exist, that Dr.Suku cured him,thereafter he referred to a doctor called Dr.Suku and told me to contact him,so i contacted Dr Suku lo and behold after 2 weeks my herpes virus was cured totally am now herpes negative by Dr.Suku Herbal medicine,so i no that there is some people that can't still believe that herpes have no cure so friends i will not lie to you Dr.Suku is a great herbalist that cure any types of Disease,HERPES.HIV/AIDS.CANCER.HEPATITIS B.LOW SPERM CAM.DIABETICS.so contact him by is email now:greatsukusolutiontemple@hotmail.com or contact his Mobil number +2348074839242 visit his website: http://greatsukusolutiont.wix.com/dr-suku

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  57. Been Herpes is just like been through hell; well special thanks to God almighty for using DR.OKOROM the greatest HERBAL CURE in curing my Herpes disease. I was diagnosed of this disease in the year 2010. Thou I was taking my medications buy I was not myself. Until last two weeks. My friend came to me and told me that he saw many testimonies on how a greatest HERBAL CURE cured people Herpes disease. Thou I never believe in HERBAL, I said to myself "seen is believing" I took his name and searched it on GOOGLE, I saw many testimonies myself. Quickly, I copied his email I emailed him, he gave me a form to fill which I did, then he called me and told me that his gods required some items in which he will use in HERBAL a curing on me. And i told him to get the listed items needed to prepare my cure because by then i have little faith in him, few hours later he called me and told me he is through preparing the cure. so he send it to me I got my parcel, it was a herbal cure as described by DR. OKOROM took the herbal cure and after taking it for a week and some days. He told me to go for check up, I went to the hospital and had a test,and i was cured. Quickly I called him and tell him what happened he congratulated me. I promise to tell the world about him. You can contact via email dr.okoromspellhome@live.com or http://dr-okorom.webs.com/

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  58. Hello my dear viewers,I am John Lual, i will say to the world to celebrate with me on this numerous testimony, i never believe i could ever get rid of this horrible disease until one fateful day,my story and appreciation goes to Dr.Suku the powerful great doctor that help me to cure my HIV/AIDS disease from my life,he is truly a truthful man with high herbs power's he uses on saving people's life, just a few days back i came in contact with Dr.Suku emails which many individuals have testify so much about of his kind work, so i decided and contacted him quickly because the disease was almost at the last minute of taking my life, i have tried all remedies from several physicians from hospitals but none could help me apart from Dr.Suku who finally cure my HIV/AIDS disease, i was amazed and overwhelmed when the doctor confirmed me negative in the same hospital i have been before,i wish to anyone that is sick today and want healing to please contact this doctor called greatsukusolutiontemple@hotmail.com so if you have any problem HIV, HERPES, CANCER, ALS,HEPATITIS B, DIABETIC,or call +2348074839242.via website; http://greatsukusolutiont.wix.com/dr-suku thanks sir.

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  59. Greetings to all viewers...i was diagnosed of herpes since 2010,i have be living with this deadly disease for the past seven years now,all my efforts to be cured was in vain,until i met my school friend who told of a herbalist that cure herpes, so i contacted the herbal doctor and told him about my disease and then he assured me not to worry that after two weeks i must be cured,just as he said hopefully i was indeed cured,and now i am totally healed of herpes and happy,all thanks to Dr.Akuna for the work well done,you can contact him through his emai:(DRAKUNASOLUTIONTEMPLE@GMAIL.COM).or his mobile number:+2348154625070,and he can cure any types of disease too,HIV/AIDS,DIABETICS,HEPATITIS B,CANCER, ALS, I'm so grateful to Dr.Akuna with person like him i know many life will be save,thank you Dr.Akuna. email
    DRAKUNASOLUTIONTEMPLE@GMAIL.COM

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  60. Help me thank Dr Ehigie.am happy to share this grate news,i am here today with grate joy in my heart to testify on how Dr Ehigie Helped me create a complete family. I have been married for 6years without Happiness (A SON), have visited many medical doctor and herbal doctor here in UK but no one could help me and my husband has grate love for babies but it was hard for us, we were at the stage of loosing all hope when i was referred to an African Herbal Doctor, The lady that directed me to him said Dr Ehigie cured her of Herpes infection and she assured me that he is a professional that he can solve all problem, i actually contacted him and explain how i have suffered for 6 years and he told me to be happy that i will be able to conceive a child after 20days of his herbal treatment, i said AMEN and followed his process and he sent me a Herbal Medicine with instruction regarding consumption for 20 days and i did exactly as he said. Glory be to Almighty God for using Dr Ehigie to shame my enemies, my child is 3 years old and i am pregnant again. I now have a happy family, When i look at my husband i see grate joy in him unlike before when we don't have a child. You will not know how happy and fulfilled i am now if you are not childless. My heart desire is considered GRANTED with the intervention of DR Ehigie. You can contact him via Email: dr.ehigiehomeofsolution@gmail.com,He can also solve menopause, Menstruation problems, Low sperm count, Loose weight. He can as well Help you get your lover or husband back, Contact Dr EHIGIE and get your heart desire granted. Email.dr.ehigiehomeofsolution@gmail.com....

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  61. Help me thank Dr Ehigie.am happy to share this grate news,i am here today with grate joy in my heart to testify on how Dr Ehigie Helped me create a complete family. I have been married for 6years without Happiness (A SON), have visited many medical doctor and herbal doctor here in UK but no one could help me and my husband has grate love for babies but it was hard for us, we were at the stage of loosing all hope when i was referred to an African Herbal Doctor, The lady that directed me to him said Dr Ehigie cured her of Herpes infection and she assured me that he is a professional that he can solve all problem, i actually contacted him and explain how i have suffered for 6 years and he told me to be happy that i will be able to conceive a child after 20days of his herbal treatment, i said AMEN and followed his process and he sent me a Herbal Medicine with instruction regarding consumption for 20 days and i did exactly as he said. Glory be to Almighty God for using Dr Ehigie to shame my enemies, my child is 3 years old and i am pregnant again. I now have a happy family, When i look at my husband i see grate joy in him unlike before when we don't have a child. You will not know how happy and fulfilled i am now if you are not childless. My heart desire is considered GRANTED with the intervention of DR Ehigie. You can contact him via Email: dr.ehigiehomeofsolution@gmail.com,He can also solve menopause, Menstruation problems, Low sperm count, Loose weight. He can as well Help you get your lover or husband back, Contact Dr EHIGIE and get your heart desire granted. Email.dr.ehigiehomeofsolution@gmail.com....

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  62. I was diagnose of hep B for more than 2 years, all the medical doctors said to me there is no cure but it can only be control. Ever since then i have been running heather scepter looking for a solution to my problem, i ran into this online testimony of Mrs Stacey who have been cured of Hep B by this medical center she mention, i immediately contacted them, to God be thy glory i also got my cure am so happy today, please my advice is, if you have been living with Hep B contact them now don't waste time and get cured here is also their email healthmedlab@gmail.com

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  63. I was diagnosed of DIABETES over 6years, I have tried all possible means to get cure but all my effort proved abortive, until a friend of mine introduced me to a herbal doctor from South Africa, who prepare herbal medicine to cure all kind of diseases including hepatitis b virus DIABETES (HBV), CANCER.( HIV) ALS FATTY LIVER SIMPLEX Hepatitis B/C, when i contacted this herbal doctor via his email, he sent me DIABETES herbal medicine via courier service, when i received the herbal medicine he gave me step by step instructions on how to apply it, when i applied it as instructed i was totally cured from the virus within few weeks of usage.my God will Bless you great Dr.i will continue sharing this testimonies in everywhere across the world, Contact this great herbal doctor via his email
    herbalcliniccentre@gmail.com

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  64. Good day to you all friends, my name is Smith Brandy from United State,I have been suffering from (HERPES) disease for the last four years and had constant pains, especially in my knees. During the first year,I had faith in God that i would be healed someday. This disease started circulating all over my body and i have been taking treatment from my doctor, few weeks ago i came searching on the internet if i could get any information concerning the cure of this disease, on my search i saw a testimony of someone who has been cured of genital herpes by this Man Dr Agbaka and she also gave the email address of this man and advise me to contact him for any sickness that he would be of help, so i wrote to Dr Agbaka telling him about my (HERPES Virus) he told me not to worry that i was going to be cured!! hmm i never believed it,, well after all the procedures and remedy given to me by this man, few weeks later i started experiencing changes all over me as Dr Agbaka assured me, after some time i went to my doctor to confirm if i have be finally cured, behold it was TRUE, So friends my advise is if you have such sickness or any other at all you can email Dr Agbaka on : (agbakaherbalhome@gmail.com) or call and watsapp him with +2348077126783.. THESE ARE THE THINGS DR AGBAKA CAN ALSO CURE: GENITAL WARTS, HIV/AIDS , LOW SPERM COUNT, MENOPAUSE DISEASE, STROKE, Bring back ex lover or wife/husband....sir i am indeed grateful for the help i will forever recommend you to my friends!!!

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  65. Hello my dear viewers,I am John Lual, i will say to the world to celebrate with me on this numerous testimony, i never believe i could ever get rid of this horrible disease until one fateful day,my story and appreciation goes to Dr.Suku the powerful great doctor that help me to cure my HIV/AIDS disease from my life,he is truly a truthful man with high herbs power's he uses on saving people's life, just a few days back i came in contact with Dr.Suku emails which many individuals have testify so much about of his kind work, so i decided and contacted him quickly because the disease was almost at the last minute of taking my life, i have tried all remedies from several physicians from hospitals but none could help me apart from Dr.Suku who finally cure my HIV/AIDS disease, i was amazed and overwhelmed when the doctor confirmed me negative in the same hospital i have been before,i wish to anyone that is sick today and want healing to please contact this doctor called greatsukusolutiontemple@hotmail.com so if you have any problem HIV, HERPES, CANCER, ALS,HEPATITIS B, DIABETIC,or call +2348074839242.via website; http://greatsukusolutiont.wix.com/dr-suku thanks sir.

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  66. I never believed i would be healed someday.This disease started circulate all over my body and i have been taking treatment from my doctor, few weeks ago i came on search on the internet if i could get any information concerning the prevention of this disease, on my search i saw a testimony of someone who has been healed from (Hepatitis B and Cancer) by this Man dr.okorom and she also gave the email address of this man and advise we should contact him for any sickness that he would be of help, so i wrote to dr.okoromspellhome@live.com telling him about my (HERPES Virus) he told me not to worry that i was going to be cured!! hmm i never believed it,, well after all the procedures and remedy given to me by this man few weeks later i started experiencing changes all over me as the Doctor Shapson assured me that i have cured,after some time i went to my Dr to confirmed if i have be finally healed behold it was TRUE, So friends my advise is if you have such sickness or any other at all you can email dr.okorom on : dr.okoromspellhome@live.com or call +2348158168556 http://dr-okorom.webs.com/

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  67. I'm glad to be reading this article, I simply want to offer you a huge thumbs up for your great information.
    Tableau Guru
    www.sqiar.com

    ReplyDelete
  68. I have been suffering from (HERPES SIMPLEX VIRUS) disease for the past four years and had constant pain, especially in my knees. During the first year,I had faith in God that i would be healed someday.This disease started circulating all over my body and i have been taking treatment from my doctor, few weeks ago i came on search on the internet if i could get any information concerning the prevention of this disease, on my search i saw a testimony of someone who has been healed from (Hepatitis B and Cancer) by this Man Dr JOSH and she also gave the email address of this man and advise we should contact him for any sickness that he would be of help, so i wrote to Dr. JOSH telling him about my (HERPES Virus) he told me not to worry that i was going to be cured!! hmm i never believed it,, well after all the procedures and remedy given to me by this man few weeks later i started experiencing changes all over me as the Dr assured me that i have cured,after some time i went to my doctor to confirmed if i have be finally healed behold it was TRUE, So friends my advise is if you have such sickness or any other at all you can email Dr JOSH drjoshhealingtemple@gmail.com or call him on +2349033455855

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  69. I want to tell the world Dr Ofemo have cure my HERPES VIRUS,for like 8 years Now I have been in pain suffering from HERPES VIRUS,but one day as I was surfing through the Internet i came across testimony in the internet on how Dr Ofemo Cure herpes patient and HIV/AIDS patient,I decided to give it a try to see if he could cure my herpes,and i follow the instruction he gave to me, to my greatest surprise after 2 week i was free from my herpes. I'm now here to testify that am No more a herpes patient, and now am so much happy,a great herbalist that treats and cure all manner of diseases like, HEPATITIS B CURE OR CANCER OR HIV&AIDS contact him now.drofemospelltemple@gmail.com to get your miraculous Herbal cured.his email via drofemospelltemple@yahoo.com or his web/site: http://drofemospelltemple.wix.com/dr-ofemo or cell number +2348163387496 thank you Dr Ofemo your herbal medicine is a powerful herbs for saving the world herpes disease.all thank to you Sir Ofemo.

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  70. Hello Dr aloma herbal medicines are great,, i was diagnosed with Herpatitis B, I started taking some vitamins and other prescribed medications but i wasn’t cured, I saw a comment about Dr.aloma on how he cured someone with herbal medicine, and it takes 9 days for the patient to get cured, I contacted him and he guided me. I asked for solutions he started the remedies for my health, he sent me the medicine ups COURIER SERVICE. I received the parcel a week later, so I started taking the medicine as prescribed by him, within 14 days i started to see some changes in my body, and before the completion of the 14 days i was cured, so I’m urging you to contact him for help, he’s the only one that help you get cured from the virus and once you are cured you are cured forever, its not reversible okay! you can reach him on )dralomaherbscure@gmail.com)(dralomaherbalcure@outlook.com) all thank you dr aloma

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  71. GET RID OF HSV1-2 BY A HERBALIST DOCTOR CALL DR OLUBAOLUBA OF AFRICAN.
    ,
    i want to give almighty praise to DR OLUBAOLUBA who help me cure Herpes simplex virus, please help me to give thanks to him he is a great man who God send from heaven to save people’s life, when i contacted this deadly virus i thought that was the end of the world, latter did i know that there is a man called DR OLUBAOLUBA OF AFRICA who has made a breakthrough in the cure of HSV-1 and HSV-2 cure with herbs which i confided in a friend here in SOUTH AFRICA he told me about this man called DR OLUBAOLUBA and how he cured the mum and dad of HSV-1 and HSV-2 after two years of living with this deadly diseases he told me of the cost and procedure i felt it worth a try after i have been spending so much in the drugs to make me live like every normal human being so i contacted DR OLUBAOLUBA and did as he commanded without missing words he did all he needed to do and sent me the herbs here in south Africa through DHL i took it as he directed it was exactly 14 days as DR OLUBAOLUBA has spoken when he emailed me and told me to go for a check up again and i went, to my greatest surprise i tested negative i felt it was a dream so i went to three different hospital and it was still negative then i cried out in a loud voice and people gathered in the hospital and i told them my story in tears how this man called DR OLUBAOLUBA have saved my life and they started demanding for his mail to contact him it was only last week my friend Vanessa who was HSV positive came back from visiting DR OLUBAOLUBA as a healthy woman i told her about DR OLUBAOLUBA you can reach him through his emai address olubahivherbalcure@gmail.com or +2348131258106 he never fails hold on my friend don't cry no more when our helper is here i believe in him am sure you will be lucky as i am too just email him on olubahivherbalcure@gmail.com he is a savior of life.....

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  72. Dr. khumalo God will continue to bless you more abundantly, for the good works you are doing in peoples life, I will keep on writing and posting testimonies about you on the Internet, I’m faith Stacey, I was a HBsag patient, I saw a blog on how Dr. Khumalo cured someone, I contacted him and also got my healing, kindly email him now on healthmedlab@gmail.com THESE ARE THE THINGS Dr. Khumalo DO. HERPES, WITCH CRAFT PROBLEM,HIV/AIDS. CANCER. ALS Hepatitis B/C .NEED YOUR EX BACK, PERFECT CHARM, NEED A BABY, thank you and God bless you for saving my life healthmedlab@gmail.com

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  73. i can’t believe this is unbelievable how Dr itua cure my herpes simplex virus, since 2 year ago i was effected with HERPES VIRUS, and i have taking all manner of drugs prescribed to me from several doctors,but all my effort was wasted,i cry all the day thinking on how i can be cure, i lost all hope,so i was looking for solution for my health,but one faithful day, i was searching the internet i came across several testimonies about Dr.itua, how he has cure so many effected individual,so i try and contact his via email, DOCTORITUAHERBALHOME@GMAIL.COM, and asked him for solution about my herpes virus and he started the preparation to my cure,to my greatest surprise after three week, i was totally cure by his powerful herbal medicine, i received from Dr.itua,i never believe that i could be cure from my herpes simplex until i met Dr.itua i’m very grateful to you Sir itua and i know your herbal medicine will save more million lives.and he cure all manner of disease like HIV, HERPES, HEPATITIS B, CANCER, DIABETES,thank you Sir itua for curing my herpes virus,his email DOCTORITUAHERBALHOME@GMAIL.COM or Have is Mobil number+2348162075224.

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  74. I have been suffering from (HERPES SIMPLEX VIRUS) disease for the past four years and had constant pain, especially in my knees. During the first year,I had faith in God that i would be healed someday.This disease started circulating all over my body and i have been taking treatment from my doctor, few weeks ago i came on search on the internet if i could get any information concerning the prevention of this disease, on my search i saw a testimony of someone who has been healed from (Hepatitis B and Cancer) by this Man Dr sukuju and she also gave the email address of this man and advise we should contact him for any sickness that he would be of help, so i wrote to Dr. sukuju telling him about my (HERPES Virus) he told me not to worry that i was going to be cured!! hmm i never believed it,,well after all the procedures and remedy given to me by this man few weeks later i started experiencing changes all over me as the Dr assured me that i have cured,after some time i went to my doctor to confirmed if i have be finally healed behold it was TRUE, So friends my advise is if you have such sickness or any other at all you can email :drsukujuspelltemple@gmail.com

    ReplyDelete
  75. I have been suffering from (HERPES SIMPLEX VIRUS) disease for the past four years and had constant pain, especially in my knees. During the first year,I had faith in God that i would be healed someday.This disease started circulating all over my body and i have been taking treatment from my doctor, few weeks ago i came on search on the internet if i could get any information concerning the prevention of this disease, on my search i saw a testimony of someone who has been healed from (Hepatitis B and Cancer) by this Man Dr sukuju and she also gave the email address of this man and advise we should contact him for any sickness that he would be of help, so i wrote to Dr. sukuju telling him about my (HERPES Virus) he told me not to worry that i was going to be cured!! hmm i never believed it,,well after all the procedures and remedy given to me by this man few weeks later i started experiencing changes all over me as the Dr assured me that i have cured,after some time i went to my doctor to confirmed if i have be finally healed behold it was TRUE, So friends my advise is if you have such sickness or any other at all you can email :drsukujuspelltemple@gmail.com

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  76. Hi my name is Joyce from England, I want to thank DR TWINS for helping me Getting Rid of my HPV/WART disease. I was Diagnosed of this Virus for two years but after the Usage of DR TWINS Herbal Medicine, I was Cured and up till now, The Symptoms of the HPV/WART is completely Gone.. So anyone who wants to reach DR TWINS should do that by email him peacehelpmedicalcentre@hotmail.com Good luck

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  77. hello everybody ,please this testimony is true life story ,is real ,am a very honest man ,i can never post false testimony on social media ,so let me go straight to the point .me and my wife was diagnosed with HPV/WART for two years,living a life of fear for two good years .until one day i saw a post about a good herbalist in west Africa curing people from a deadly disease,such HIV/AIDS, HERPES (HSV1, HSV2), (HPV) ACUTE RETROVIRAL SYNDROME (ARS), CANCER, VITILIGO, DIABETES, HEPATITIS B. CANCER, CELIAC, ALS, CHLAMYDIA, STROKE and any kind of Deadly DISEASES,with his herbal medicine and he is also a spell caster, i thought it was not true,then i said let me try ,because am used to trying ,i have been trying for two years, until that day GOD wipe my tears,with DR TWINS, He his gifted ,and he is so honest ,so easy to get along with ,so after i contacted him via his email. (peacehelpmedicalcentre@hotmail.com ),so he replied and said my problem is solved that i must stop thinking,so i believed and have faith that i will be cured ,so i purchased the herbal medicine and he sent the herbal medicine to me through courier service ,when i received it ,he told me how to use it ,so i followed exactly the way he said i must use it,he said i will be totally cured after two weeks ,so after two week i went to see our family doctor he tested me and said am negative ,i was so happy i thought i was dreaming ,please don:t ignore this post ,if you think is not real try and you will testify just like me ....thanks to DR TWINS ,GOD BLESS you sir, you can also contact me carlscamejo@gmail.com.

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  78. I am from New York. I was in trouble when doctor told me that I have been diagnosed with Genital Herpes… I though about my Family, I know my Family will face a serious problem when I’m gone, I lost hope and I wept all day, but one day I was surfing the internet I found Dr. INIBOKU contact number. I called him and he guided me. I asked him for solutions and he started the remedies for my health. Thank God, now everything is fine, I’m cured by Dr.INIBOKU herbal medicine, I’m very thankful to Dr. INIBOKU and very happy with my hubby and family. email him on drinibokuspelltemple@gmail.com OR or drinibokuspelltemple@outlook.com.

    DOCTOR INIBOKU CAN AS WELL CURE THE FOLLOWING DISEASE:-

    1. HIV/AIDS

    2. HERPES

    3. CANCER

    4. ALS

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  79. Really like the dear information you offer in your articles. I’m able to bookmark your site and show the kids check out up here generally.
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    ReplyDelete
  80. This is how DR IDIALU helped me in getting rid of my HERPES SIMPLEX 2 VIRUS
    disease. I am TRACY BEN my email address is tracyben12345@gmail.com i was diagnosed of
    this disease for over FIVE years i have be looking for solution until January this year.
    thought all hope is lost, I was half dead just because of the pain I was separated from the crowd and i was now alone,truly I was in a great pain, I tried all my best
    to be happy again but I can’t, until a good friend of mine introduced a
    great SPIRITUALHEALLER to me who is DR.IDIALU, saying that she saw many
    testimonies on how he helped people getting rid of their HERPES SIMPLEX Virus he gave
    me his email which is okhihiespelltemple@gmail.com. I spoke to him and being a kindhearted man he answered me without any delay. I told him
    my problems, he asked me to buy some items, and though I couldn’t find the
    items I sent him the money to buy the items for me. Which he did
    successfully, he cast the spell, before he prepared the herbal. he send it to me via corrie service and he instructed me on how to take the herbal. and asked me to go for medical checkup
    which I did, I didn’t believe when the doctor told me that am HERPES SIMPLEX VIRUS negative,
    truly am still short of words, I thank DR.IDIALU for the great deeds, if you
    are having a similar problem I will advice you to contact dr IDIALU on his email okhihiespelltemple@gmail.com

    ReplyDelete
  81. I am indeed very happy for my life; I never thought that I will live on earth before the year runs out. I have been suffering from a deadly disease [HERPS] for the past 2 years now; I had spent a lot of money going from one places to another, from churches to churches, hospitals have been my every day residence. Constant checks up have been my hobby but until this faithful day, I was searching through the internet, I saw a testimony on how a spell caster helped someone in curing his HERPS disease, quickly I copied his email which is doctorumiefanherbalcentre@gmail.com
    I spoke to him, he asked me to do some certain things which I did, he told me that he is going to cast the spell which he did, then he asked me to go for medical checkup after 45 minutes of casting the spell, I was free from the deadly disease, he only asked me to post the testimony through the whole world, faithfully am doing it now, please brothers and sisters, he is great, I own him my life, if you are having a similar problem or suffering from HERPS,HIV,ALS,MND,CANCER just email him on doctorumiefanherbalcentre@gmail.com or call him on +2348134470041... A word is enough for the wise...

    ReplyDelete
  82. Hello my lovingly guest reading this article right now i am so glad to be writing this article today to tell the world how Dr Suku cured my herpes,i have been detected with Herpes Simplex since five years ago, ever since then my life has been in complete bizarre and agony,i have used so many drugs that was prescribed to me by several doctors,but it didn't cure my Herpes neither did it reduce the pain,until a certain i was checking for solution in the internet,then miraculously came across Dr Suku the powerful herbalist that cure numerous individuals Herpes,then i contacted his email:greatsukusolutiontemple@hotmail.com, i explained everything to him and prepared a cure that cure my herpes disease totally after receiving his herbal medicine, so my dear viewers why wait and suffer when there is someone like Dr Suku that can cure you too, you can contact his Mobil number:+2348074839242 or his website:http://greatsukusolutiont.wix.com/dr-suku

    ReplyDelete
  83. Hello everyone am here to express my joy about how i got cure from a herbal doctor, i never knew i was ever going to get rid of this illness until i meet this herbal doctor called DR ODOMA, introduced to me by a friend of mine who also have this horrible and disgusting illness, i have tour round the hospitals all i keep hearing is that i will have to be taken much of dosage everyday just so subsidy the pain and inching and it keep having a sharp pain in the area that are affected, i couldn't bear the pain and the disgrace i have endure just to mention some view of my encounters with HSV1 AND HSV2, it is not an illness i want anyone to be infected with in fact i prefer HIV-AIDS to HSV1 AND HSV2. because you can still leave with it without thinking of the next second or minutes your body is going to start up again with all the horrible sharp biting and inching, this is how i met DR ODOMA introduced to me by my friend name is Susan Gorge re-email me that he has all it takes to get rid of any illness that the science have not be able to come up with the medication, so i press further to ask questions i start wondering how come the medication i have being taken are not responding to my immune system, he explained everything to me that it is the wonders of the Almighty God and the FORE-FATHER who laid down everything for him when he was very little and with his hard work and proper study of ROOT AND HERBS he finally arrived at a stage where all he has labored for and study hard to understand the names of the root and herbs he started helping people to get cure just to say few because if i start i will never stop talking and writing. so after so much talk he proceed to the medication tell me how to get the HERPES medication and how to use it that after 8 days the herpes will be gone and there is nothing like side effect or after some time or years it will be reoccurring again. so i proceed to the items and he send it to me through DHL i received within a week because it takes 4 working days to get to me .so if you want to reach him just email him with his address odomaspelltemple@outlook.com or call his cellphone number +2348076054350....

    ReplyDelete
  84. My name is Christabella, I am here to Share my testimony about a doctor who helped me remove a burden from my life. I was infected with HERPES SIMPLEX VIRUS in 2012, i went to many hospitals for cure but there was no solution, so I was thinking of how to get a solution out so that my body can be okay. One day I went to visit a friend and she asked why i was looking so sad i explained to her my problem, she told me that she can help me out, she introduced me to a doctor who uses herbal medication to cure HERPES SIMPLEX VIRUS and gave me his email, so i emailed him. He told me all the things I needed to do and also gave me instructions to take, which I followed properly. Before I knew what was happening after two weeks the HERPES SIMPLEX VIRUS that was in my body vanished . so if you are also heart broken and also need a help, you can also email him at: drkakuduwesthealingcenter@gmail.com OR dr.kakuduwesthealingtemple@outlook.com
    Doctor Kakudu CAN AS WELL CURE THE FOLLOWING DISEASE:-
    HIV/AIDS,HERPES,CANCER,ALS

    ReplyDelete
  85. I'm giving a testimony about DR Aziegbe the great Herbalist, he has the cure to all manner of diseases, he cured my herpes simplex virus, though I went through different website I saw different testimonies about different spell casters and herbalist, I was like: 'Many people's have the herpes simplex virus cure why are people still suffering from it?' I though of it, then I contact DR Aziegbe via email, I didn't believe him that much, I just wanted to give him a try, he replied my mail and Needed some Information about me, then I sent them to him, he prepared it (CURE) and sent it to me through Airfreight Online Courier Service for delivery, he gave my details to the Courier Office, they told me that 2-3 days I will receive the parcel and i took the medicine as prescribed by him and I went for check-up 2 week after finishing the medicine, I was tested herpes simplex virus negative, if you are herpes simplex virus patient do me a favor by you contacting him and I assure anyone who is suffering it,your problem will never remain the same again you will be cured.ALSO DR Aziegbe help my sister husband to cure his HIV/AIDS he was suffering from it for the past 3 years, After he {cure} my herpes simplex virus, then my sister heard about it, she went home to tell her husband about DR aziegbe then her husband email him and explain his problem to him, he also prepare herbal medicine and he use Airfreight courier service to sent him the herbal medicine and he instruct him on how he will be using it for 14 days, That on the 15 days of it, he should go and check his self in the hospital and he did as he was instructed by DR Aziegbe to GOD be the glory he was cure of his HIV/AIDS which he was suffering from for the past 3 years thanks to these great man we will ever remain grateful to you sir indeed might work you did in our families. When you contact him, make sure you tell him that I refer you.. contact him via: DRAZIEGBEHERBALHOMEOFSOLUTION@GMAIL.COM

    ReplyDelete

  86. I want to share my testimonies on how Dr Timothy cured me from Genetic Herpes with his herbal medicine, he was very honest ,he told me i will be cured within 8days that was what happened ,he sent me the herbal medicine ,which i did not spend much ,i have been cheated by some fake herbalist ,till God directed me to dr Timothy,now am free from the deadly disease,please don't ignore this post is for real ,he cures other deadly disease ..contact him via his email drtimothyhealingtemple@gmail.com if you need help . To hell with the government and their insane policy, he have a medication that is hundred percent assured to cure genital herpes and some other deadly diseases ,you don't need to spend so much money anymore

    ReplyDelete
  87. i was ever going to be HERPES Negative again,Dr Olokum has given me reasons to be happy, i was HERPES positive for 2years and all the means i tried for treatment was not helpful to me, but when i came on the Internet i saw great testimony about Dr Olokum on how he was able to cure someone from HERPES, this person said great things about this man, and advice we contact him for any Disease problem that Dr Olokum can be of help, well i decided to give him a try, he requested for my information which i sent to him, and he told me he was going to prepare for me a healing portion, which he wanted me to take for days, and after which i should go back to the hospital for check up, well after taking all the treatment sent to me by Dr Olokum i went back to the Hospital for check up, and now i have been confirmed HERPES Negative, friends you can reach Dr olokum on any treatment for any Disease he is the one only i can show you all up to, reach him on drolokumspelltemple@gmail.com or call +2348161554365

    ReplyDelete
  88. Good day to you all friends, my name is Kelly John from United State,I have been suffering from (HERPES) disease for the last four years and had constant pain, especially in my knees. During the first year,I had faith in God that i would be healed someday.This disease started circulate all over my body and i have been taking treatment from my doctor, few weeks ago i came on search on the internet if i could get any information concerning the prevention of this disease, on my search i saw a testimony of someone who has been healed from (Hepatitis B and Cancer) by this Man Dr OCUSODO and she also gave the email address of this man and advise me to contact him for any sickness that he would be of help, so i wrote to Dr OCUSODO telling him about my (HERPES Virus) he told me not to worry that i was going to be cured!! hmm i never believed it,, well after all the procedures and remedy given to me by this man, few weeks later i started experiencing changes all over me as Dr OCUSODO assured me that i have cured,after some time i went to my doctor to confirmed if i have be finally healed, behold it was TRUE, So friends my advise is if you have such sickness or any other at all you can email Dr OCUSODO on : (drocusodospellcaster@gmail.com) OR (drocusodospellcaster@yahoo.com) call him with +2348105578036 .. THESE ARE THE THINGS Dr OCUSODO CAN ALSO CURING OF GENITAL WARTS,GONORRHEA, HIV/AIDS , LOW SPERM COUNT, MENOPAUSE DISEASE, PREGNANCY PROBLEM, SHORTSIGHTEDNESS PROBLEM, STROKE, Bring back ex lover or wife/husband....sir i am indeed grateful for the help i will forever recommend you to my friends!!!

    ReplyDelete
  89. I really happy that i and my boyfriend are cured of (HERPES SIMPLEX VIRUS) with the herbal medicine of Dr aigbehi , i have been suffering from this disease for the past 3 years without solution until i came across the email of this doctors who have cure so many people with his herbal medicine, i also choose to give him a chance to help me and my boyfriend, he told me what to do and i kindly did it, and he gave us his herbal medicine and direct me on how to use it, i also follows his instruction for use and he ask us to go for a check up after 3 weeks and which i did, to my greatest surprise our result came out as negative, we are really happy that there is someone like this DR who is ready to help anytime any day. to all the readers and viewers that is doubting this testimony stop doubting it and contact this Dr and see if he will not actually help you. i am not a stupid woman that i will come out to the public and start saying what someone have not done for me. he is really a great man contact him now. with this emailhe is waiting for your calls.+2347036842735 email: draigbehispellhome@gmail.com

    ReplyDelete
  90. My name is Maria HERNANDEZ i am from USA, I am here to give my testimony about a doctor who helped me in my life. I was infected with HERPES in 2013, i went to many hospitals for cure but there was no solution, so I was thinking how can I get a solution out so that my body can be okay. One day I was in the river side thinking where I can go to get solution. so a lady walked to me telling me why am I so sad and i open up all to her telling her my problem,that i have herpes genital she told me that she can help me out, she introduce me to a doctor who uses herbal medication to cure HERPES and gave me his email, so i mail him. He told me all the things I need to do and also gave me instructions to take, which I followed properly. Before I knew what is happening after one week the HERPES that was in my body got cured . so if you are having herpes or any kind of disease listed below and you also want cure, you can also email him at: dr.ighodalocuringhome@gmail.com
    . HERPES
    . HIV/AIDS
    . CANCER
    kindly email DR.IGHODALO for your cleansing and have a happy life bye.

    ReplyDelete
  91. I'm giving a testimony about DR Aziegbe the great Herbalist, he has the cure to all manner of diseases, he cured my herpes simplex virus, though I went through different website I saw different testimonies about different spell casters and herbalist, I was like: 'Many people's have the herpes simplex virus cure why are people still suffering from it?' I though of it, then I contact DR Aziegbe via email, I didn't believe him that much, I just wanted to give him a try, he replied my mail and Needed some Information about me, then I sent them to him, he prepared it (CURE) and sent it to me through Airfreight Online Courier Service for delivery, he gave my details to the Courier Office, they told me that 2-3 days I will receive the parcel and i took the medicine as prescribed by him and I went for check-up 2 week after finishing the medicine, I was tested herpes simplex virus negative, if you are herpes simplex virus patient do me a favor by you contacting him and I assure anyone who is suffering it,your problem will never remain the same again you will be cured.ALSO DR Aziegbe help my sister husband to cure his HIV/AIDS he was suffering from it for the past 3 years, After he {cure} my herpes simplex virus, then my sister heard about it, she went home to tell her husband about DR aziegbe then her husband email him and explain his problem to him, he also prepare herbal medicine and he use Airfreight courier service to sent him the herbal medicine and he instruct him on how he will be using it for 14 days, That on the 15 days of it, he should go and check his self in the hospital and he did as he was instructed by DR Aziegbe to GOD be the glory he was cure of his HIV/AIDS which he was suffering from for the past 3 years thanks to these great man we will ever remain grateful to you sir indeed might work you did in our families. When you contact him, make sure you tell him that I refer you.. contact him via: DRAZIEGBEHERBALHOMEOFSOLUTION@GMAIL.COM

    ReplyDelete
  92. I want to share my testimony on how i get cure of my HERPES GENITAL with the help of Doctor Lusanda,i have being suffering for this disease for a very long time now.i have try several means to get rid of of the (HERPES) disease for the last four years and had constant pain, especially in my knees. During the first year,I had faith in God that i would be healed someday.This disease started circulate all over my body and i have been taking treatment from my doctor, few weeks ago i came on search on the internet if i could get any information concerning the prevention of this disease, on my search i saw a testimony of someone who has been healed from (Hepatitis B and Cancer) by this Man DR Lusanda and she also gave the email address of this man and advise we should contact him for any sickness that he would be of help, so i wrote to DR Lusanda telling him about my (HERPES Virus) he told me not to worry that i was going to be cured!! hmm i never believed it,, well after all the procedures and remedy given to me by this man few weeks later i started experiencing changes all over me as the Doctor assured me that i am cured,after some time i went to my doctor to confirmed if i have be finally healed behold it was TRUE, So friends my advise is if you have such sickness or any other at all you can email DR Lusanda on drlusandaherbal@gmail.com sir i am indeed grateful for the help i will forever recommend you to my friends and to share this to every one that have any of this sickness

    ReplyDelete
  93. Hello everyone my names are Christina missy , i am here to testify about a great herbal spell caster called Dr Eromosele who helped me cure my HERPES SIMPLEX VIRUS . I was infected with HERPES SIMPLEX VIRUS in 2014, i went to many hospitals for cure but there was no solution, so I was thinking how can I get a solution out so that my body can be okay. So One day I went on line on the Internet to know more clue about the Herpes Simplex Virus i came across a review of a lady saying that she got her Herpes Simplex Virus cured by A great herbal spell caster Called Dr Eromosele. And she also went as far to drop an email address and including Dr Eromosele telephone number and advise anyone to contact Dr Eromosele for any kind of help. So i gave a try by contacting him through his email and explain my problem to him. He told me all the things I need to do and also give me instructions to take, which I followed properly. Before I knew what is happening after two weeks the HERPES SIMPLEX VIRUS that was in my body got vanished, contact him email: dreromoselespellhome@gmail.com or call his telephone number +2347038110398

    ReplyDelete
  94. I have been suffering from (HERPES) disease for the last four years and had constant pain, especially in my knees. During the first year,I had faith in God that i would be healed someday.This disease started circulate all over my body and i have been taking treatment from my doctor, few weeks ago i came on search on the internet if i could get any information concerning the prevention of this disease, on my search i saw a testimony of someone who has been healed from (Hepatitis B and Cancer) by this Man Dr itua and she also gave the email address of this man and advise we should contact him for any sickness that he would be of help, so i wrote to Dr. itua telling him about my (HERPES Virus) he told me not to worry that i was going to be cured!! hmm i never believed it,, well after all the procedures and remedy given to me by this man few weeks later i started experiencing changes all over me as the Dr assured me that i have cured,after some time i went to my doctor to confirmed if i have be finally healed behold it was TRUE, So friends my advise is if you have such sickness or any other at all you can email Dr. itua on : doctorituaherbalhome@gmail.com sir i am indeed grateful for the help i will forever recommend you to my friends!!! with your lovely Email Address doctorituaherbalhome@gmail.com THANKS SO MUCH DOCTOR or call his phone number on +2349055346811.

    ReplyDelete
  95. My name is Christabella, I am here to Share my testimony about a doctor who helped me remove a burden from my life. I was infected with HERPES SIMPLEX VIRUS in 2012, i went to many hospitals for cure but there was no solution, so I was thinking of how to get a solution out so that my body can be okay. One day I went to visit a friend and she asked why i was looking so sad i explained to her my problem, she told me that she can help me out, she introduced me to a doctor who uses herbal medication to cure HERPES SIMPLEX VIRUS and gave me his email, so i emailed him. He told me all the things I needed to do and also gave me instructions to take, which I followed properly. Before I knew what was happening after two weeks the HERPES SIMPLEX VIRUS that was in my body vanished . so if you are also heart broken and also need a help, you can also email him at: drkakuduwesthealingcenter@gmail.com OR dr.kakuduwesthealingtemple@outlook.com
    Doctor Kakudu CAN AS WELL CURE THE FOLLOWING DISEASE:-
    HIV/AIDS,HERPES,CANCER,ALS

    ReplyDelete
  96. Get the cure to low sperm count, weak erection and premature ejaculation problem from Dr Alegbe, my wife left me because i was not able to perform on bed,and because of that we were childless,Dr Alegbe sent his product(medication) to me which i used and it is a permanent cure to weak erection and premature ejaculation my new wife is pregnant now, so i give all thanks to Dr Alegbe for making me a man again,i was cured with is product.Dr Alegbe contact is alegbejohn7@gmail.com or +2349027116105

    ReplyDelete
  97. I've had genital Herpes problem over 4 years. I tried everything, of course I went to the medical DR. about a hundred times, probably not that many times , but it sure seems like nothing works . It never did any good for long and caused all kinds of other issues having to do with taking too many antibiotics. It wasn't easy until I stumbled upon this natural remedy , of a great prophet who cures with natural herbal herbs by name PROPHET WILLIAMS i email him and explain my situations and he advised me on this herbal cure which i gave a try, and my life changed completely. I'm feeling so much better now and all of my symptoms are totally gone. I haven't had an outbreak since using that, and am now tested negative info. prophetwilliamsspiritualtemple@gmail.com contact him for any disease like ALS,HEPATITIS B, DIABETIC, HSV2 HIV, HERPES, CANCER, ANTHRAX he is the only solution medical doctors will fail and disappoint you. info prophetwilliamsspiritualtemple@gmail.com thanks prophet you are the best.

    ReplyDelete
  98. I have been suffering from (HERPES) disease for the last four years and had constant pain, especially in my knees. During the first year,I had faith in God that i would be healed someday.This disease started circulate all over my body and i have been taking treatment from my doctor, few weeks ago i came on search on the internet if i could get any information concerning the prevention of this disease, on my search i saw a testimony of someone who has been healed from (Hepatitis B and Cancer) by this Man Dr INIBOKU and she also gave the email address of this man and advise we should contact him for any sickness that he would be of help, so i wrote to Dr. INIBOKU telling him about my (HERPES Virus) he told me not to worry that i was going to be cured!! hmm i never believed it,, well after all the procedures and remedy given to me by this man few weeks later i started experiencing changes all over me as the Dr assured me that i have cured,after some time i went to my doctor to confirmed if i have be finally healed behold it was TRUE, So friends my advise is if you have such sickness or any other at all you can email Dr.INIBOKU on : drinibokuspelltemple@gmail.com sir i am indeed grateful for the help i will forever recommend you to my friends!!! with your lovely Email Address drinibokuspelltemple@gmail.com

    THANKS SO MUCH DOCTOR

    ReplyDelete
  99. I have been suffering from (HERPES) disease for the last four years and had constant pain, especially in my knees. During the first year,I had faith in God that i would be healed someday.This disease started circulate all over my body and i have been taking treatment from my doctor, few weeks ago i came on search on the internet if i could get any information concerning the prevention of this disease, on my search i saw a testimony of someone who has been healed from (Hepatitis B and Cancer) by this Man Dr INIBOKU and she also gave the email address of this man and advise we should contact him for any sickness that he would be of help, so i wrote to Dr. INIBOKU telling him about my (HERPES Virus) he told me not to worry that i was going to be cured!! hmm i never believed it,, well after all the procedures and remedy given to me by this man few weeks later i started experiencing changes all over me as the Dr assured me that i have cured,after some time i went to my doctor to confirmed if i have be finally healed behold it was TRUE, So friends my advise is if you have such sickness or any other at all you can email Dr.INIBOKU on : drinibokuspelltemple@gmail.com sir i am indeed grateful for the help i will forever recommend you to my friends!!! with your lovely Email Address drinibokuspelltemple@gmail.com

    THANKS SO MUCH DOCTOR

    ReplyDelete
  100. THANK YOU FOR SAVING MY SISTER LIFE DR. OKUNS!!! I NEVER BELIEVED IN THIS UNTIL I GIVE A TRY, YOU SHOULD GIVE A TRY TOO! STOP ASKING DOUBTING QUESTIONS.
    I am Mary Hanson by name, from USA. I want the general public
    to know how this great man called Dr. Okuns cure my sister from GENITAL HERPES with the herbal medicine gotten from Dr. Okuns, he cures other diseases too I have suffered for Human papilloma virus HPV) for 2years he cure me too, herbal is a great medication. he have a medicine that is 100% percent assured to cure genital herpes and you don't need to spend so much money anymore . I want you to contact Dr. Okuns on: herbal.home247@yahoo.com My family is now a brand new one, so stop your worries and go get your herbal medicine now to get your family free from deadly disease. Once again thanks to Dr. Okuns you can contact him now via phone number: +2348078467513 or email him on: herbal.home247@yahoo.com

    ReplyDelete
  101. hello I'm Dave from Switzerland, I have been suffering from HERPES disease for the past 4 years and i had constant pain especially in my knees, During the first year I had faith in God that i will be healed someday,This disease started circulate all over my body and i have been taking treatment from my doctor, few weeks ago i came in search on the internet if i could get any information concerning the prevention of this disease, on my search i saw a testimony of so many people who has been healed from Hepatitis B, HIV AID, Diabetes, ALS and Cancer and so many diseases by this Man called Dr, Ovia, and he also gave the email address of this man and advise we should contact him for any sickness that he would be of help, so i wrote to Dr. Ovia telling him about my HERPES Virus he told me not to worry that i will be cured from this deadly disease i never believed it, well after all the procedures and remedy given to me by this man, few weeks later i started experiencing changes all over me as the Dr. Ovia assured me that i will be cured,after some time i went to my medical doctor to confirmed if i have be finally cured behold it was true,and now i m cure totally with Dr. Ovia medication, So friends my advise is if you have such sickness or any other at all you can email Dr,Ovia on this email dr.oviaspiritualherbaltemple@gmail.com or call him on whats app number +2348135858735 for assistance. he will help you also , good luck....

    ReplyDelete
  102. I am so so happy today, I have been suffering from HIV for the past 3years now, i have spent a lot getting drugs from the hospital to keep me healthy, i have tried all means in life to become HIV negative , but there was no answer until i decided to try herbal solution and i found Great Dr. BULUKONA in an online research i contacted him and after his powerful intervention I'm so glad that i am now HIV Negative, i am very very happy, thank you Great Dr. BULUKONA for helping my life come back newly again without any form of crisis, i promise to tell your name and good deeds to the whole world. Kindly contact him for cure regarding, HIV, Herpes, Cancer and other disease. Email: bulukonasolutiontemple@outlook.com ,Website: bulukonasolutiontemple.webs.com, call or text +2347068047006

    ReplyDelete
  103. I am so so happy today, I have been suffering from HIV for the past 3years now, i have spent a lot getting drugs from the hospital to keep me healthy, i have tried all means in life to become HIV negative , but there was no answer until i decided to try herbal solution and i found Great Dr. BULUKONA in an online research i contacted him and after his powerful intervention I'm so glad that i am now HIV Negative, i am very very happy, thank you Great Dr. BULUKONA for helping my life come back newly again without any form of crisis, i promise to tell your name and good deeds to the whole world. Kindly contact him for cure regarding, HIV, Herpes, Cancer and other disease. Email: bulukonasolutiontemple@outlook.com ,Website: bulukonasolutiontemple.webs.com, call or text +2347068047006

    ReplyDelete